Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study

This post hoc subgroup analysis examined efficacy and safety outcomes with extended thromboprophylaxis rivaroxaban compared with in-hospital enoxaparin in 2,078 patients from the MAGELLAN study who had a hospitalization for heart failure or a history of heart failure and a lower risk of bleeding. A...

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Autores principales: Spyropoulos, Alex C., Raskob, Gary E., Spiro, Theodore E., Lu, Wentao, De Sanctis, Yoriko, Albanese, John, Mebazaa, Alexandre, Barnathan, Elliot S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546607/
https://www.ncbi.nlm.nih.gov/pubmed/36299620
http://dx.doi.org/10.1055/a-1926-2489
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author Spyropoulos, Alex C.
Raskob, Gary E.
Spiro, Theodore E.
Lu, Wentao
De Sanctis, Yoriko
Albanese, John
Mebazaa, Alexandre
Barnathan, Elliot S.
author_facet Spyropoulos, Alex C.
Raskob, Gary E.
Spiro, Theodore E.
Lu, Wentao
De Sanctis, Yoriko
Albanese, John
Mebazaa, Alexandre
Barnathan, Elliot S.
author_sort Spyropoulos, Alex C.
collection PubMed
description This post hoc subgroup analysis examined efficacy and safety outcomes with extended thromboprophylaxis rivaroxaban compared with in-hospital enoxaparin in 2,078 patients from the MAGELLAN study who had a hospitalization for heart failure or a history of heart failure and a lower risk of bleeding. A significant 36% reduction in the composite endpoint of asymptomatic proximal deep vein thrombosis (DVT) in the lower extremity, symptomatic DVT in the lower extremity (proximal or distal), symptomatic nonfatal pulmonary embolism, and venous thromboembolism-related death was observed with rivaroxaban. Major bleeding was low in both groups and not significantly increased with rivaroxaban.
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spelling pubmed-95466072022-10-25 Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study Spyropoulos, Alex C. Raskob, Gary E. Spiro, Theodore E. Lu, Wentao De Sanctis, Yoriko Albanese, John Mebazaa, Alexandre Barnathan, Elliot S. TH Open This post hoc subgroup analysis examined efficacy and safety outcomes with extended thromboprophylaxis rivaroxaban compared with in-hospital enoxaparin in 2,078 patients from the MAGELLAN study who had a hospitalization for heart failure or a history of heart failure and a lower risk of bleeding. A significant 36% reduction in the composite endpoint of asymptomatic proximal deep vein thrombosis (DVT) in the lower extremity, symptomatic DVT in the lower extremity (proximal or distal), symptomatic nonfatal pulmonary embolism, and venous thromboembolism-related death was observed with rivaroxaban. Major bleeding was low in both groups and not significantly increased with rivaroxaban. Georg Thieme Verlag KG 2022-10-07 /pmc/articles/PMC9546607/ /pubmed/36299620 http://dx.doi.org/10.1055/a-1926-2489 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Spyropoulos, Alex C.
Raskob, Gary E.
Spiro, Theodore E.
Lu, Wentao
De Sanctis, Yoriko
Albanese, John
Mebazaa, Alexandre
Barnathan, Elliot S.
Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study
title Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study
title_full Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study
title_fullStr Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study
title_full_unstemmed Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study
title_short Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study
title_sort extended thromboprophylaxis in hospitalized patients with heart failure: a post hoc analysis of the magellan study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546607/
https://www.ncbi.nlm.nih.gov/pubmed/36299620
http://dx.doi.org/10.1055/a-1926-2489
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