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Discovering design principles of collagen molecular stability using a genetic algorithm, deep learning, and experimental validation
Collagen is the most abundant structural protein in humans, providing crucial mechanical properties, including high strength and toughness, in tissues. Collagen-based biomaterials are, therefore, used for tissue repair and regeneration. Utilizing collagen effectively during materials processing ex v...
Autores principales: | Khare, Eesha, Yu, Chi-Hua, Gonzalez Obeso, Constancio, Milazzo, Mario, Kaplan, David L., Buehler, Markus J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546622/ https://www.ncbi.nlm.nih.gov/pubmed/36161946 http://dx.doi.org/10.1073/pnas.2209524119 |
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