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FGFR redundancy limits the efficacy of FGFR4-selective inhibitors in hepatocellular carcinoma

Aberrant fibroblast growth factor 19 (FGF19) signaling mediated by its receptor, FGF receptor 4 (FGFR4), and coreceptor, klotho β (KLB), is a driver of hepatocellular carcinoma (HCC). Several potent FGFR4-selective inhibitors have been developed but have exhibited limited efficacy in HCC clinical tr...

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Detalles Bibliográficos
Autores principales: Tao, Zhanchao, Cui, Yue, Xu, Xilong, Han, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546626/
https://www.ncbi.nlm.nih.gov/pubmed/36179047
http://dx.doi.org/10.1073/pnas.2208844119

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