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The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats

This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administra...

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Autores principales: Khaled, Shimaa S., Soliman, Hanan A., Abdel-Gabbar, Mohammed, Ahmed, Noha A., Attia, Kandil Abdel Hai Ali, Mahran, Hesham A., El-Nahass, El-Shaymaa, Ahmed, Osama M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546692/
https://www.ncbi.nlm.nih.gov/pubmed/36212979
http://dx.doi.org/10.1155/2022/8739815
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author Khaled, Shimaa S.
Soliman, Hanan A.
Abdel-Gabbar, Mohammed
Ahmed, Noha A.
Attia, Kandil Abdel Hai Ali
Mahran, Hesham A.
El-Nahass, El-Shaymaa
Ahmed, Osama M.
author_facet Khaled, Shimaa S.
Soliman, Hanan A.
Abdel-Gabbar, Mohammed
Ahmed, Noha A.
Attia, Kandil Abdel Hai Ali
Mahran, Hesham A.
El-Nahass, El-Shaymaa
Ahmed, Osama M.
author_sort Khaled, Shimaa S.
collection PubMed
description This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administration of naringin and/or naringenin 10 mg/kg body weight every other day, was continued for six weeks. Treatment of rats with naringin and/or naringenin significantly reversed elevated serum creatinine, urea, and uric acid levels caused by paclitaxel, reflecting improved kidney function. Similarly, heart dysfunction induced by paclitaxel was alleviated after treatment with naringin and/or naringenin, as evidenced by significant decreases in elevated CK-MB and LDH activities. After drug administration, histopathological findings and lesion scores in the kidneys and heart were markedly decreased by naringin and/or naringenin. Moreover, the treatments reversed renal and cardiac lipid peroxidation and the negative impacts on antioxidant defenses via raising GSH, SOD, and GPx. The preventive effects of naringin and naringenin were associated with suppressing oxidative stress and reestablishing antioxidant defenses. A combination of naringin and naringenin was the most efficacious in rescuing organ function and structure.
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spelling pubmed-95466922022-10-08 The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats Khaled, Shimaa S. Soliman, Hanan A. Abdel-Gabbar, Mohammed Ahmed, Noha A. Attia, Kandil Abdel Hai Ali Mahran, Hesham A. El-Nahass, El-Shaymaa Ahmed, Osama M. Evid Based Complement Alternat Med Research Article This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administration of naringin and/or naringenin 10 mg/kg body weight every other day, was continued for six weeks. Treatment of rats with naringin and/or naringenin significantly reversed elevated serum creatinine, urea, and uric acid levels caused by paclitaxel, reflecting improved kidney function. Similarly, heart dysfunction induced by paclitaxel was alleviated after treatment with naringin and/or naringenin, as evidenced by significant decreases in elevated CK-MB and LDH activities. After drug administration, histopathological findings and lesion scores in the kidneys and heart were markedly decreased by naringin and/or naringenin. Moreover, the treatments reversed renal and cardiac lipid peroxidation and the negative impacts on antioxidant defenses via raising GSH, SOD, and GPx. The preventive effects of naringin and naringenin were associated with suppressing oxidative stress and reestablishing antioxidant defenses. A combination of naringin and naringenin was the most efficacious in rescuing organ function and structure. Hindawi 2022-09-30 /pmc/articles/PMC9546692/ /pubmed/36212979 http://dx.doi.org/10.1155/2022/8739815 Text en Copyright © 2022 Shimaa S. Khaled et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Khaled, Shimaa S.
Soliman, Hanan A.
Abdel-Gabbar, Mohammed
Ahmed, Noha A.
Attia, Kandil Abdel Hai Ali
Mahran, Hesham A.
El-Nahass, El-Shaymaa
Ahmed, Osama M.
The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats
title The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats
title_full The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats
title_fullStr The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats
title_full_unstemmed The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats
title_short The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats
title_sort preventive effects of naringin and naringenin against paclitaxel-induced nephrotoxicity and cardiotoxicity in male wistar rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546692/
https://www.ncbi.nlm.nih.gov/pubmed/36212979
http://dx.doi.org/10.1155/2022/8739815
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