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The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats
This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administra...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546692/ https://www.ncbi.nlm.nih.gov/pubmed/36212979 http://dx.doi.org/10.1155/2022/8739815 |
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author | Khaled, Shimaa S. Soliman, Hanan A. Abdel-Gabbar, Mohammed Ahmed, Noha A. Attia, Kandil Abdel Hai Ali Mahran, Hesham A. El-Nahass, El-Shaymaa Ahmed, Osama M. |
author_facet | Khaled, Shimaa S. Soliman, Hanan A. Abdel-Gabbar, Mohammed Ahmed, Noha A. Attia, Kandil Abdel Hai Ali Mahran, Hesham A. El-Nahass, El-Shaymaa Ahmed, Osama M. |
author_sort | Khaled, Shimaa S. |
collection | PubMed |
description | This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administration of naringin and/or naringenin 10 mg/kg body weight every other day, was continued for six weeks. Treatment of rats with naringin and/or naringenin significantly reversed elevated serum creatinine, urea, and uric acid levels caused by paclitaxel, reflecting improved kidney function. Similarly, heart dysfunction induced by paclitaxel was alleviated after treatment with naringin and/or naringenin, as evidenced by significant decreases in elevated CK-MB and LDH activities. After drug administration, histopathological findings and lesion scores in the kidneys and heart were markedly decreased by naringin and/or naringenin. Moreover, the treatments reversed renal and cardiac lipid peroxidation and the negative impacts on antioxidant defenses via raising GSH, SOD, and GPx. The preventive effects of naringin and naringenin were associated with suppressing oxidative stress and reestablishing antioxidant defenses. A combination of naringin and naringenin was the most efficacious in rescuing organ function and structure. |
format | Online Article Text |
id | pubmed-9546692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-95466922022-10-08 The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats Khaled, Shimaa S. Soliman, Hanan A. Abdel-Gabbar, Mohammed Ahmed, Noha A. Attia, Kandil Abdel Hai Ali Mahran, Hesham A. El-Nahass, El-Shaymaa Ahmed, Osama M. Evid Based Complement Alternat Med Research Article This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administration of naringin and/or naringenin 10 mg/kg body weight every other day, was continued for six weeks. Treatment of rats with naringin and/or naringenin significantly reversed elevated serum creatinine, urea, and uric acid levels caused by paclitaxel, reflecting improved kidney function. Similarly, heart dysfunction induced by paclitaxel was alleviated after treatment with naringin and/or naringenin, as evidenced by significant decreases in elevated CK-MB and LDH activities. After drug administration, histopathological findings and lesion scores in the kidneys and heart were markedly decreased by naringin and/or naringenin. Moreover, the treatments reversed renal and cardiac lipid peroxidation and the negative impacts on antioxidant defenses via raising GSH, SOD, and GPx. The preventive effects of naringin and naringenin were associated with suppressing oxidative stress and reestablishing antioxidant defenses. A combination of naringin and naringenin was the most efficacious in rescuing organ function and structure. Hindawi 2022-09-30 /pmc/articles/PMC9546692/ /pubmed/36212979 http://dx.doi.org/10.1155/2022/8739815 Text en Copyright © 2022 Shimaa S. Khaled et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Khaled, Shimaa S. Soliman, Hanan A. Abdel-Gabbar, Mohammed Ahmed, Noha A. Attia, Kandil Abdel Hai Ali Mahran, Hesham A. El-Nahass, El-Shaymaa Ahmed, Osama M. The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats |
title | The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats |
title_full | The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats |
title_fullStr | The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats |
title_full_unstemmed | The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats |
title_short | The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats |
title_sort | preventive effects of naringin and naringenin against paclitaxel-induced nephrotoxicity and cardiotoxicity in male wistar rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546692/ https://www.ncbi.nlm.nih.gov/pubmed/36212979 http://dx.doi.org/10.1155/2022/8739815 |
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