Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond

Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in OPRM1, has been identified as a genome-wide significant association with OA and independently replicated. We applied genomic structural equation modeling to conduct a GWAS of the new Genetics of Opioid Addiction...

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Detalles Bibliográficos
Autores principales: Gaddis, Nathan, Mathur, Ravi, Marks, Jesse, Zhou, Linran, Quach, Bryan, Waldrop, Alex, Levran, Orna, Agrawal, Arpana, Randesi, Matthew, Adelson, Miriam, Jeffries, Paul W., Martin, Nicholas G., Degenhardt, Louisa, Montgomery, Grant W., Wetherill, Leah, Lai, Dongbing, Bucholz, Kathleen, Foroud, Tatiana, Porjesz, Bernice, Runarsdottir, Valgerdur, Tyrfingsson, Thorarinn, Einarsson, Gudmundur, Gudbjartsson, Daniel F., Webb, Bradley Todd, Crist, Richard C., Kranzler, Henry R., Sherva, Richard, Zhou, Hang, Hulse, Gary, Wildenauer, Dieter, Kelty, Erin, Attia, John, Holliday, Elizabeth G., McEvoy, Mark, Scott, Rodney J., Schwab, Sibylle G., Maher, Brion S., Gruza, Richard, Kreek, Mary Jeanne, Nelson, Elliot C., Thorgeirsson, Thorgeir, Stefansson, Kari, Berrettini, Wade H., Gelernter, Joel, Edenberg, Howard J., Bierut, Laura, Hancock, Dana B., Johnson, Eric Otto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546890/
https://www.ncbi.nlm.nih.gov/pubmed/36207451
http://dx.doi.org/10.1038/s41598-022-21003-y

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