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Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis
Transthyretin (TTR) is a tetrameric transport protein mainly synthesized by the liver and choroid plexus. ATTR amyloidosis is characterized by the misfolding of TTR monomers and their accumulation within tissues as amyloid fibres. Current therapeutic options rely on the blockade of TTR production, T...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546974/ https://www.ncbi.nlm.nih.gov/pubmed/35386059 http://dx.doi.org/10.1007/s10741-022-10237-7 |