Functional genomics of complex cancer genomes

Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology app...

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Detalles Bibliográficos
Autores principales: Menghi, Francesca, Liu, Edison T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547052/
https://www.ncbi.nlm.nih.gov/pubmed/36207330
http://dx.doi.org/10.1038/s41467-022-33717-8
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author Menghi, Francesca
Liu, Edison T.
author_facet Menghi, Francesca
Liu, Edison T.
author_sort Menghi, Francesca
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description Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology approaches, has revealed novel cancer vulnerabilities beyond the original paradigm of one gene-one phenotype.
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spelling pubmed-95470522022-10-09 Functional genomics of complex cancer genomes Menghi, Francesca Liu, Edison T. Nat Commun Comment Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology approaches, has revealed novel cancer vulnerabilities beyond the original paradigm of one gene-one phenotype. Nature Publishing Group UK 2022-10-07 /pmc/articles/PMC9547052/ /pubmed/36207330 http://dx.doi.org/10.1038/s41467-022-33717-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Menghi, Francesca
Liu, Edison T.
Functional genomics of complex cancer genomes
title Functional genomics of complex cancer genomes
title_full Functional genomics of complex cancer genomes
title_fullStr Functional genomics of complex cancer genomes
title_full_unstemmed Functional genomics of complex cancer genomes
title_short Functional genomics of complex cancer genomes
title_sort functional genomics of complex cancer genomes
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547052/
https://www.ncbi.nlm.nih.gov/pubmed/36207330
http://dx.doi.org/10.1038/s41467-022-33717-8
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