Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It remains unclear how loss of brain pericytes in these conditions contributes to capillary dysfunction. Here, we conduct cause-and-effect studies by optically ablating pericytes in adult and aged mice in viv...

Descripción completa

Detalles Bibliográficos
Autores principales: Berthiaume, Andrée-Anne, Schmid, Franca, Stamenkovic, Stefan, Coelho-Santos, Vanessa, Nielson, Cara D., Weber, Bruno, Majesky, Mark W., Shih, Andy Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547063/
https://www.ncbi.nlm.nih.gov/pubmed/36207315
http://dx.doi.org/10.1038/s41467-022-33464-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547063/
https://www.ncbi.nlm.nih.gov/pubmed/36207315
http://dx.doi.org/10.1038/s41467-022-33464-w

Ejemplares similares