Clinical Trial Protocol for PERFECT: A Randomised Controlled Trial Comparing the Efficiency and Tolerance of Transperineal Fusion Versus Transrectal Imaging-targeted Prostate Biopsies (CCAFU-PR1 Study)

PERFECT is a multicentre randomised controlled clinical trial that evaluates the efficiency of fusion magnetic resonance imaging–targeted biopsies in the transperineal (TP) versus transrectal (TR) approach in terms of the detection of significant cancers. Our study builds on the hypothesis that the...

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Autores principales: Touzani, Alae, Fiard, Gaëlle, Barret, Eric, Renard-Penna, Raphaële, Salin, Ambroise, Pradère, Benjamin, Rozet, François, Beauval, Jean-Baptiste, Malavaud, Bernard, Giannarini, Gianluca, Colin, Pierre, Rouprêt, Morgan, Ploussard, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Trial Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547228/
https://www.ncbi.nlm.nih.gov/pubmed/36217451
http://dx.doi.org/10.1016/j.euros.2022.09.007
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author Touzani, Alae
Fiard, Gaëlle
Barret, Eric
Renard-Penna, Raphaële
Salin, Ambroise
Pradère, Benjamin
Rozet, François
Beauval, Jean-Baptiste
Malavaud, Bernard
Giannarini, Gianluca
Colin, Pierre
Rouprêt, Morgan
Ploussard, Guillaume
author_facet Touzani, Alae
Fiard, Gaëlle
Barret, Eric
Renard-Penna, Raphaële
Salin, Ambroise
Pradère, Benjamin
Rozet, François
Beauval, Jean-Baptiste
Malavaud, Bernard
Giannarini, Gianluca
Colin, Pierre
Rouprêt, Morgan
Ploussard, Guillaume
author_sort Touzani, Alae
collection PubMed
description PERFECT is a multicentre randomised controlled clinical trial that evaluates the efficiency of fusion magnetic resonance imaging–targeted biopsies in the transperineal (TP) versus transrectal (TR) approach in terms of the detection of significant cancers. Our study builds on the hypothesis that the TP approach for prostate biopsies has at least the same diagnostic accuracy as the TR approach, with lower morbidity. Here, we describe the clinical protocol, study population, and primary and secondary outcomes.
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spelling pubmed-95472282022-10-09 Clinical Trial Protocol for PERFECT: A Randomised Controlled Trial Comparing the Efficiency and Tolerance of Transperineal Fusion Versus Transrectal Imaging-targeted Prostate Biopsies (CCAFU-PR1 Study) Touzani, Alae Fiard, Gaëlle Barret, Eric Renard-Penna, Raphaële Salin, Ambroise Pradère, Benjamin Rozet, François Beauval, Jean-Baptiste Malavaud, Bernard Giannarini, Gianluca Colin, Pierre Rouprêt, Morgan Ploussard, Guillaume Eur Urol Open Sci Trial Protocol PERFECT is a multicentre randomised controlled clinical trial that evaluates the efficiency of fusion magnetic resonance imaging–targeted biopsies in the transperineal (TP) versus transrectal (TR) approach in terms of the detection of significant cancers. Our study builds on the hypothesis that the TP approach for prostate biopsies has at least the same diagnostic accuracy as the TR approach, with lower morbidity. Here, we describe the clinical protocol, study population, and primary and secondary outcomes. Elsevier 2022-10-05 /pmc/articles/PMC9547228/ /pubmed/36217451 http://dx.doi.org/10.1016/j.euros.2022.09.007 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Trial Protocol
Touzani, Alae
Fiard, Gaëlle
Barret, Eric
Renard-Penna, Raphaële
Salin, Ambroise
Pradère, Benjamin
Rozet, François
Beauval, Jean-Baptiste
Malavaud, Bernard
Giannarini, Gianluca
Colin, Pierre
Rouprêt, Morgan
Ploussard, Guillaume
Clinical Trial Protocol for PERFECT: A Randomised Controlled Trial Comparing the Efficiency and Tolerance of Transperineal Fusion Versus Transrectal Imaging-targeted Prostate Biopsies (CCAFU-PR1 Study)
title Clinical Trial Protocol for PERFECT: A Randomised Controlled Trial Comparing the Efficiency and Tolerance of Transperineal Fusion Versus Transrectal Imaging-targeted Prostate Biopsies (CCAFU-PR1 Study)
title_full Clinical Trial Protocol for PERFECT: A Randomised Controlled Trial Comparing the Efficiency and Tolerance of Transperineal Fusion Versus Transrectal Imaging-targeted Prostate Biopsies (CCAFU-PR1 Study)
title_fullStr Clinical Trial Protocol for PERFECT: A Randomised Controlled Trial Comparing the Efficiency and Tolerance of Transperineal Fusion Versus Transrectal Imaging-targeted Prostate Biopsies (CCAFU-PR1 Study)
title_full_unstemmed Clinical Trial Protocol for PERFECT: A Randomised Controlled Trial Comparing the Efficiency and Tolerance of Transperineal Fusion Versus Transrectal Imaging-targeted Prostate Biopsies (CCAFU-PR1 Study)
title_short Clinical Trial Protocol for PERFECT: A Randomised Controlled Trial Comparing the Efficiency and Tolerance of Transperineal Fusion Versus Transrectal Imaging-targeted Prostate Biopsies (CCAFU-PR1 Study)
title_sort clinical trial protocol for perfect: a randomised controlled trial comparing the efficiency and tolerance of transperineal fusion versus transrectal imaging-targeted prostate biopsies (ccafu-pr1 study)
topic Trial Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547228/
https://www.ncbi.nlm.nih.gov/pubmed/36217451
http://dx.doi.org/10.1016/j.euros.2022.09.007
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