Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review

Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the...

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Detalles Bibliográficos
Autores principales: Hassan, Hozeifa Mohamed, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Inc. 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547251/
https://www.ncbi.nlm.nih.gov/pubmed/36304511
http://dx.doi.org/10.14218/JCTH.2022.00086
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author Hassan, Hozeifa Mohamed
Li, Jun
author_facet Hassan, Hozeifa Mohamed
Li, Jun
author_sort Hassan, Hozeifa Mohamed
collection PubMed
description Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies. In this context, this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.
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spelling pubmed-95472512022-10-26 Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review Hassan, Hozeifa Mohamed Li, Jun J Clin Transl Hepatol Review Article Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies. In this context, this article provides a concise and inclusive review of breakthroughs in ACLF animal model development. XIA & HE Publishing Inc. 2022-10-28 2022-04-28 /pmc/articles/PMC9547251/ /pubmed/36304511 http://dx.doi.org/10.14218/JCTH.2022.00086 Text en © 2022 Authors. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hassan, Hozeifa Mohamed
Li, Jun
Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review
title Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review
title_full Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review
title_fullStr Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review
title_full_unstemmed Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review
title_short Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review
title_sort prospect of animal models for acute-on-chronic liver failure: a mini-review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547251/
https://www.ncbi.nlm.nih.gov/pubmed/36304511
http://dx.doi.org/10.14218/JCTH.2022.00086
work_keys_str_mv AT hassanhozeifamohamed prospectofanimalmodelsforacuteonchronicliverfailureaminireview
AT lijun prospectofanimalmodelsforacuteonchronicliverfailureaminireview

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