Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer

This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constrai...

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Detalles Bibliográficos
Autores principales: Seol, Seung Won, Lee, Brian H., Sita, Timothy L., Devineni, Jay Ram, Kruser, Tim J., Sachdev, Sean, Gentile, Michelle, Helenowski, Irene, Mittal, Bharat B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547285/
https://www.ncbi.nlm.nih.gov/pubmed/36217428
http://dx.doi.org/10.1016/j.phro.2022.09.008
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author Seol, Seung Won
Lee, Brian H.
Sita, Timothy L.
Devineni, Jay Ram
Kruser, Tim J.
Sachdev, Sean
Gentile, Michelle
Helenowski, Irene
Mittal, Bharat B.
author_facet Seol, Seung Won
Lee, Brian H.
Sita, Timothy L.
Devineni, Jay Ram
Kruser, Tim J.
Sachdev, Sean
Gentile, Michelle
Helenowski, Irene
Mittal, Bharat B.
author_sort Seol, Seung Won
collection PubMed
description This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental D(mean)_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.
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spelling pubmed-95472852022-10-09 Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer Seol, Seung Won Lee, Brian H. Sita, Timothy L. Devineni, Jay Ram Kruser, Tim J. Sachdev, Sean Gentile, Michelle Helenowski, Irene Mittal, Bharat B. Phys Imaging Radiat Oncol Short Communication This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental D(mean)_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs. Elsevier 2022-09-24 /pmc/articles/PMC9547285/ /pubmed/36217428 http://dx.doi.org/10.1016/j.phro.2022.09.008 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Seol, Seung Won
Lee, Brian H.
Sita, Timothy L.
Devineni, Jay Ram
Kruser, Tim J.
Sachdev, Sean
Gentile, Michelle
Helenowski, Irene
Mittal, Bharat B.
Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer
title Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer
title_full Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer
title_fullStr Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer
title_full_unstemmed Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer
title_short Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer
title_sort hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547285/
https://www.ncbi.nlm.nih.gov/pubmed/36217428
http://dx.doi.org/10.1016/j.phro.2022.09.008
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