Cargando…

RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation

R-spondin 2 (RSPO2) drives the potentiation of Wnt signaling and is implicated in tumorigenesis in multiple cancers, but its role in ovarian cancer has not been investigated. Here, we reported that RSPO2 promoted the growth and metastasis of ovarian cancer through the activation of FAK/Src signaling...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Rulu, Yu, Yan, Zhu, Haiyan, Zhang, Wenyi, Qin, Yuan, Ye, Lin, Dai, Juji, Huang, Ren, Peng, Xinyan, Ye, Siqi, Lin, Ziqi, Huang, Shishun, Chong, Shuyi, Lu, Liting, Lu, Xincheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547309/ https://www.ncbi.nlm.nih.gov/pubmed/36217544 http://dx.doi.org/10.1016/j.isci.2022.105184

Ejemplares similares

PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis
por: Pan, Rulu, et al.
Publicado: (2023)

Non-invasive Bioluminescence Monitoring of Hepatocellular Carcinoma Therapy in an HCR Mouse Model
por: Zhao, Zhu, et al.
Publicado: (2019)

AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway
por: Chen, Tianke, et al.
Publicado: (2020)

The dual kinase complex FAK-Src as a promising therapeutic target in cancer
por: Bolós, Victoria, et al.
Publicado: (2010)

MMP-11 promoted the oral cancer migration and FAK/Src activation
por: Hsin, Chung-Han, et al.
Publicado: (2017)

Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway
por: Ku, Chung-Yu, et al.
Publicado: (2015)

Visualization of Src and FAK Activity during the Differentiation Process from HMSCs to Osteoblasts
por: Liao, Xiaoling, et al.
Publicado: (2012)

The Overexpression of Scaffolding Protein NEDD9 Promotes Migration and Invasion in Cervical Cancer via Tyrosine Phosphorylated FAK and SRC
por: Sima, Ni, et al.
Publicado: (2013)

The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET
por: Liao, Xiaoling, et al.
Publicado: (2013)

Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar
por: Su, Linlin, et al.
Publicado: (2016)

β-elemene inhibits non-small cell lung cancer cell migration and invasion by inactivating the FAK-Src pathway
por: Zhang, Hongbo, et al.
Publicado: (2021)

MICA Expression Is Regulated by Cell Adhesion and Contact in a FAK/Src-Dependent Manner
por: Moncayo, Gerald, et al.
Publicado: (2017)

Scutellarin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF/ERK/FAK/Src Pathway Signaling
por: Long, Lingli, et al.
Publicado: (2019)

Astaxanthin prevents osteoarthritis by blocking Rspo2-mediated Wnt/β-catenin signaling in chondrocytes and abolishing Rspo2-related inflammatory factors in macrophages
por: Zhu, Chunhui, et al.
Publicado: (2023)

Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation
por: Wang, Jing, et al.
Publicado: (2017)

FAK competes for Src to promote migration against invasion in melanoma cells
por: Kolli-Bouhafs, K, et al.
Publicado: (2014)

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3
por: Lee, Jaewon J., et al.
Publicado: (2018)

Shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of Src and FAK
por: HAO, ZHENFENG, et al.
Publicado: (2015)

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition
por: Wilson, Catherine, et al.
Publicado: (2014)

Tracing the Origin of the RSPO2 Long-Hair Allele and Epistatic Interaction between FGF5 and RSPO2 in Sapsaree Dog
por: Kang, Mingue, et al.
Publicado: (2022)

RhoA and Membrane Fluidity Mediates the Spatially Polarized Src/FAK Activation in Response to Shear Stress
por: Liu, Bo, et al.
Publicado: (2014)

Dissociation of FAK/p130(CAS)/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK
por: Yamakita, Yoshihiko, et al.
Publicado: (1999)

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks
por: Schoenherr, Christina, et al.
Publicado: (2017)

An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer
por: Tai, Yu-Ling, et al.
Publicado: (2015)

Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition
por: Horton, Edward R., et al.
Publicado: (2016)

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells
por: Schoenherr, Christina, et al.
Publicado: (2014)

Src-FAK Signaling Mediates Interleukin 6-Induced HCT116 Colorectal Cancer Epithelial–Mesenchymal Transition
por: Huang, Yu-Han, et al.
Publicado: (2023)

RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer
por: Mesci, Aruz, et al.
Publicado: (2019)

Targeting MAPK/NF-κB Pathways in Anti-Inflammatory Potential of Rutaecarpine: Impact on Src/FAK-Mediated Macrophage Migration
por: Jayakumar, Thanasekaran, et al.
Publicado: (2021)

RSPO3 is a marker candidate for predicting tumor aggressiveness in ovarian cancer
por: Gu, Haifeng, et al.
Publicado: (2020)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
por: Wang, Wenqi, et al.
Publicado: (2011)

Cilengitide inhibits osteoclast adhesion through blocking the α(v)β(3)-mediated FAK/Src signaling pathway
por: Guo, Dan-yang, et al.
Publicado: (2023)

Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signaling
por: Liu, Aibin, et al.
Publicado: (2021)

Identification of RSPO2 Fusion Mutations and Target Therapy Using a Porcupine Inhibitor
por: Li, Chong, et al.
Publicado: (2018)

Arecoline Promotes Migration of A549 Lung Cancer Cells through Activating the EGFR/Src/FAK Pathway
por: Chang, Chih-Hsiang, et al.
Publicado: (2019)

COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling
por: Wang, Ting, et al.
Publicado: (2020)

Association of WNT7B and RSPO1 with Axial Length in School Children
por: Lu, Shi Yao, et al.
Publicado: (2020)

MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway
por: Jang, Te-Hsuan, et al.
Publicado: (2022)

Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells
por: Kriz, Vitezslav, et al.
Publicado: (2018)

Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRC-Paxillin Cascade Pathway
por: Wu, Guo-Sheng, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_l1jalcrsci7vvfmar2jnc5o27p