Cargando…

KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition

KCNH6 has been proven to affect glucose metabolism and insulin secretion both in humans and mice. Further study revealed that Kcnh6 knockout (KO) mice showed impaired glucose tolerance. However, the precise function of KCNH6 in the liver remains unknown. Mitochondria have been suggested to maintain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ying-Chao, Xiong, Feng-Ran, Cheng, Cheng, Shen, Han, Zhao, Ru-Xuan, Zhu, Juan-Juan, Zhang, Lin, Lu, Jing, Yang, Jin-Kui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547380/ https://www.ncbi.nlm.nih.gov/pubmed/36217412 http://dx.doi.org/10.1155/2022/3739556

Ejemplares similares

Cisapride induced hypoglycemia via the KCNH6 potassium channel
por: Lu, Jing, et al.
Publicado: (2022)

Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
por: Zhao, Miao-Miao, et al.
Publicado: (2021)

Author Correction: Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
por: Zhao, Miao-Miao, et al.
Publicado: (2021)

Novel KCNH1 Mutations Associated with Epilepsy: Broadening the Phenotypic Spectrum of KCNH1-Associated Diseases
por: von Wrede, Randi, et al.
Publicado: (2021)

Is KCNH1 mutation related to coronary artery ectasia
por: Noori, Mohammad Rafi, et al.
Publicado: (2019)

Protective effect of KCNH2 single nucleotide polymorphism K897T in LQTS families and identification of novel KCNQ1 and KCNH2 mutations
por: Zhang, Xianqin, et al.
Publicado: (2008)

Clinical Feature, Treatment, and KCNH5 Mutations in Epilepsy
por: Hu, Xiufu, et al.
Publicado: (2022)

Structure of the C-terminal Region of a KCNH Channel
por: Brelidze, Tinatin I., et al.
Publicado: (2012)

The structural mechanism of KCNH-channel regulation by the eag domain
por: Haitin, Yoni, et al.
Publicado: (2013)

KCNH3 Predicts Poor Prognosis and Promotes Progression in Ovarian Cancer
por: Li, Zhongjun, et al.
Publicado: (2020)

Structural Properties of PAS Domains from the KCNH Potassium Channels
por: Adaixo, Ricardo, et al.
Publicado: (2013)

Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels
por: Dai, Gucan, et al.
Publicado: (2018)

Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels
por: Dai, Gucan, et al.
Publicado: (2017)

Anesthetic Care of a Child Harboring the KCNH2 Gene
por: Ghimire, Anuranjan, et al.
Publicado: (2022)

Association between polymorphisms in NOS3 and KCNH2 and social memory
por: Henningsson, Susanne, et al.
Publicado: (2015)

N- and C-terminal interactions in KCNH channels: The spotlight on the intrinsic ligand
por: Brelidze, Tinatin I.
Publicado: (2019)

Gating and regulation of KCNH (ERG, EAG, and ELK) channels by intracellular domains
por: Codding, Sara J., et al.
Publicado: (2020)

Kcnh1 Voltage-gated Potassium Channels Are Essential for Early Zebrafish Development
por: Stengel, Rayk, et al.
Publicado: (2012)

Association Study of KCNH7 Polymorphisms and Individual Responses to Risperidone Treatment in Schizophrenia
por: Wang, Xueping, et al.
Publicado: (2019)

An uncommon clinical presentation of relapsing dilated cardiomyopathy with identification of sequence variations in MYNPC3, KCNH2 and mitochondrial tRNA cysteine
por: Guillen Sacoto, Maria J., et al.
Publicado: (2015)

Electrophysiological Characteristics of the LQT2 Syndrome Mutation KCNH2-G572S and Regulation by Accessory Protein KCNE2
por: Liu, Li, et al.
Publicado: (2016)

Circulating KCNH2 Current-Activating Factor in Patients with Heart Failure and Ventricular Tachyarrhythmia
por: Sugiyama, Hiroki, et al.
Publicado: (2011)

Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a
por: Yelin-Bekerman, Laura, et al.
Publicado: (2015)

The intrinsically liganded cyclic nucleotide–binding homology domain promotes KCNH channel activation
por: Zhao, Yaxian, et al.
Publicado: (2017)

S186. KCNH2 POLYMORPHISM ASSOCIATED TO ALTERED EEG FUNCTIONAL NETWORK MODULATION IN SCHIZOPHRENIA
por: Juárez, Alba Lubeiro, et al.
Publicado: (2018)

Maternal mosaicism in long QT syndrome due to a pathogenic variant in KCNH2
por: Sawyer, Briana L., et al.
Publicado: (2020)

Potassium Channel KCNH1 Activating Variants Cause Altered Functional and Morphological Ciliogenesis
por: Napoli, Giulia, et al.
Publicado: (2022)

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains
por: Lörinczi, Éva, et al.
Publicado: (2015)

Case Report: Biventricular Noncompaction Cardiomyopathy With Pulmonary Stenosis and Bradycardia in a Fetus With KCNH2 Mutation
por: Sun, Hairui, et al.
Publicado: (2022)

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses
por: Engelbrechtsen, Line, et al.
Publicado: (2018)

Phenotypic expansion of KCNH1 ‐associated disorders to include isolated epilepsy and its associations with genotypes and molecular sub‐regional locations
por: Tian, Mao‐Qiang, et al.
Publicado: (2022)

Functional study of a KCNH2 mutant: Novel insights on the pathogenesis of the LQT2 syndrome
por: De Zio, Roberta, et al.
Publicado: (2019)

The KCNH3 inhibitor ASP2905 shows potential in the treatment of attention deficit/hyperactivity disorder
por: Takahashi, Shinji, et al.
Publicado: (2018)

Mexiletine shortens the QT interval in a pedigree of KCNH2 related long QT syndrome
por: Fujisawa, Taishi, et al.
Publicado: (2020)

A standardised hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity
por: Oliveira‐Mendes, Barbara, et al.
Publicado: (2021)

Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance
por: Copier, Jaël S, et al.
Publicado: (2022)

Integrated analysis of the voltage-gated potassium channel-associated gene KCNH2 across cancers
por: Zheng, Zequn, et al.
Publicado: (2023)

Mechanisms of fever-induced QT prolongation and torsades de pointes in patients with KCNH2 mutation
por: Usuda, Keisuke, et al.
Publicado: (2023)

A Novel KCNH2 S981fs Mutation Identified by Whole-Exome Sequencing Is Associated with Type 2 Long QT Syndrome
por: Cheng, Yu-Wen, et al.
Publicado: (2023)

Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 Cells
por: Zhang, Juan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_g7h1prh7qj3jst4sm7n5umcg1s