Primary Spinal Epidural Diffuse Large B-cell Lymphoma: Case Report and Literature Review

Primary spinal epidural lymphoma (PSEL) comprises a group of tumors present only in the spinal epidural space with a histopathological picture of lymphoma and negative diagnostic workup for lymphoma at other sites. We present the case of an older male adult with primary spinal diffuse large B-cell l...

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Autores principales: Bhardwaj, Prarthna V, Abraham, Annie, Alluri, Sunitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Radiation Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547554/
https://www.ncbi.nlm.nih.gov/pubmed/36237782
http://dx.doi.org/10.7759/cureus.28934
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author Bhardwaj, Prarthna V
Abraham, Annie
Alluri, Sunitha
author_facet Bhardwaj, Prarthna V
Abraham, Annie
Alluri, Sunitha
author_sort Bhardwaj, Prarthna V
collection PubMed
description Primary spinal epidural lymphoma (PSEL) comprises a group of tumors present only in the spinal epidural space with a histopathological picture of lymphoma and negative diagnostic workup for lymphoma at other sites. We present the case of an older male adult with primary spinal diffuse large B-cell lymphoma (DLBCL) presenting with spinal cord compression who was treated with surgery followed by high dose methotrexate in combination with RCHOP (rituximab, cyclophosphamide, prednisone, vincristine, and doxorubicin). This case report and review of literature on DLBCL limited to the spine provide a novel chemotherapy regimen and a comprehensive perspective on the optimal management of these patients.
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spelling pubmed-95475542022-10-12 Primary Spinal Epidural Diffuse Large B-cell Lymphoma: Case Report and Literature Review Bhardwaj, Prarthna V Abraham, Annie Alluri, Sunitha Cureus Radiation Oncology Primary spinal epidural lymphoma (PSEL) comprises a group of tumors present only in the spinal epidural space with a histopathological picture of lymphoma and negative diagnostic workup for lymphoma at other sites. We present the case of an older male adult with primary spinal diffuse large B-cell lymphoma (DLBCL) presenting with spinal cord compression who was treated with surgery followed by high dose methotrexate in combination with RCHOP (rituximab, cyclophosphamide, prednisone, vincristine, and doxorubicin). This case report and review of literature on DLBCL limited to the spine provide a novel chemotherapy regimen and a comprehensive perspective on the optimal management of these patients. Cureus 2022-09-08 /pmc/articles/PMC9547554/ /pubmed/36237782 http://dx.doi.org/10.7759/cureus.28934 Text en Copyright © 2022, Bhardwaj et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiation Oncology
Bhardwaj, Prarthna V
Abraham, Annie
Alluri, Sunitha
Primary Spinal Epidural Diffuse Large B-cell Lymphoma: Case Report and Literature Review
title Primary Spinal Epidural Diffuse Large B-cell Lymphoma: Case Report and Literature Review
title_full Primary Spinal Epidural Diffuse Large B-cell Lymphoma: Case Report and Literature Review
title_fullStr Primary Spinal Epidural Diffuse Large B-cell Lymphoma: Case Report and Literature Review
title_full_unstemmed Primary Spinal Epidural Diffuse Large B-cell Lymphoma: Case Report and Literature Review
title_short Primary Spinal Epidural Diffuse Large B-cell Lymphoma: Case Report and Literature Review
title_sort primary spinal epidural diffuse large b-cell lymphoma: case report and literature review
topic Radiation Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547554/
https://www.ncbi.nlm.nih.gov/pubmed/36237782
http://dx.doi.org/10.7759/cureus.28934
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