Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids

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While pluripotent stem cell-derived kidney organoids are now being used to model renal disease, the proximal nephron remains immature with limited evidence for key functional solute channels. This may reflect early mispatterning of the nephrogenic mesenchyme and/or insufficient maturation. Here we s...

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Detalles Bibliográficos
Autores principales: Vanslambrouck, Jessica M., Wilson, Sean B., Tan, Ker Sin, Groenewegen, Ella, Rudraraju, Rajeev, Neil, Jessica, Lawlor, Kynan T., Mah, Sophia, Scurr, Michelle, Howden, Sara E., Subbarao, Kanta, Little, Melissa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547573/
https://www.ncbi.nlm.nih.gov/pubmed/36209212
http://dx.doi.org/10.1038/s41467-022-33623-z
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