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A Narrative Review of STAT Proteins in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects
Diabetic retinopathy (DR), a blinding disease, is one of the high-incidence chronic complications of diabetes. However, the current treatment for DR is mainly based on advanced pathological changes, which cannot reverse pre-existing retinal tissue damage and visual impairment. Signal transducer and...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547576/ https://www.ncbi.nlm.nih.gov/pubmed/36208390 http://dx.doi.org/10.1007/s40123-022-00581-0 |
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author | Hong, Libing Lin, Yongqi Yang, Xiongyi Wu, Tong Zhang, Yuxi Xie, Zhuohang Yu, Jieli Zhao, Hejia Yi, Guoguo Fu, Min |
author_facet | Hong, Libing Lin, Yongqi Yang, Xiongyi Wu, Tong Zhang, Yuxi Xie, Zhuohang Yu, Jieli Zhao, Hejia Yi, Guoguo Fu, Min |
author_sort | Hong, Libing |
collection | PubMed |
description | Diabetic retinopathy (DR), a blinding disease, is one of the high-incidence chronic complications of diabetes. However, the current treatment for DR is mainly based on advanced pathological changes, which cannot reverse pre-existing retinal tissue damage and visual impairment. Signal transducer and activator of transcription (STAT) proteins are essential in DR through early and late stages. They participate in the early stage of DR through multiple mechanisms and have a strong proangiogenic effect in the late stage. Inhibiting STAT proteins activity has also achieved a significant effect in reversing the pathological changes of DR. Thus, STAT proteins are expected to be an effective therapeutic target in the early stage of DR and can make up for inadequate late treatment. This review introduces the structure, signal transduction mode, and biological functions of STAT proteins in detail and focuses on their role in the mechanism of DR. We also summarize the current research on STAT-related biological agents in DR, aiming to provide a theoretical basis for the treatment of DR. |
format | Online Article Text |
id | pubmed-9547576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-95475762022-10-11 A Narrative Review of STAT Proteins in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects Hong, Libing Lin, Yongqi Yang, Xiongyi Wu, Tong Zhang, Yuxi Xie, Zhuohang Yu, Jieli Zhao, Hejia Yi, Guoguo Fu, Min Ophthalmol Ther Review Diabetic retinopathy (DR), a blinding disease, is one of the high-incidence chronic complications of diabetes. However, the current treatment for DR is mainly based on advanced pathological changes, which cannot reverse pre-existing retinal tissue damage and visual impairment. Signal transducer and activator of transcription (STAT) proteins are essential in DR through early and late stages. They participate in the early stage of DR through multiple mechanisms and have a strong proangiogenic effect in the late stage. Inhibiting STAT proteins activity has also achieved a significant effect in reversing the pathological changes of DR. Thus, STAT proteins are expected to be an effective therapeutic target in the early stage of DR and can make up for inadequate late treatment. This review introduces the structure, signal transduction mode, and biological functions of STAT proteins in detail and focuses on their role in the mechanism of DR. We also summarize the current research on STAT-related biological agents in DR, aiming to provide a theoretical basis for the treatment of DR. Springer Healthcare 2022-10-08 2022-12 /pmc/articles/PMC9547576/ /pubmed/36208390 http://dx.doi.org/10.1007/s40123-022-00581-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Review Hong, Libing Lin, Yongqi Yang, Xiongyi Wu, Tong Zhang, Yuxi Xie, Zhuohang Yu, Jieli Zhao, Hejia Yi, Guoguo Fu, Min A Narrative Review of STAT Proteins in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects |
title | A Narrative Review of STAT Proteins in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects |
title_full | A Narrative Review of STAT Proteins in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects |
title_fullStr | A Narrative Review of STAT Proteins in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects |
title_full_unstemmed | A Narrative Review of STAT Proteins in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects |
title_short | A Narrative Review of STAT Proteins in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects |
title_sort | narrative review of stat proteins in diabetic retinopathy: from mechanisms to therapeutic prospects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547576/ https://www.ncbi.nlm.nih.gov/pubmed/36208390 http://dx.doi.org/10.1007/s40123-022-00581-0 |
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