Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions

The 40-year-old experience with glucocorticosteroids (GCs) in the context of severe infections is complex and troublesome. Recently, however, a clear indication for GCs in severe COVID-19 has been established. This may constitute a harbinger of a wider use of GCs in critical illnesses. A fundamental...

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Autores principales: Winkler, Martin S., Osuchowski, Marcin F., Payen, Didier, Torres, Antoni, Dickel, Steffen, Skirecki, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547674/
https://www.ncbi.nlm.nih.gov/pubmed/36209188
http://dx.doi.org/10.1186/s13054-022-04185-9
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author Winkler, Martin S.
Osuchowski, Marcin F.
Payen, Didier
Torres, Antoni
Dickel, Steffen
Skirecki, Tomasz
author_facet Winkler, Martin S.
Osuchowski, Marcin F.
Payen, Didier
Torres, Antoni
Dickel, Steffen
Skirecki, Tomasz
author_sort Winkler, Martin S.
collection PubMed
description The 40-year-old experience with glucocorticosteroids (GCs) in the context of severe infections is complex and troublesome. Recently, however, a clear indication for GCs in severe COVID-19 has been established. This may constitute a harbinger of a wider use of GCs in critical illnesses. A fundamental prerequisite of such an action is a better understanding of the heterogeneity of critical illness and GCs operationalization within the precision medicine approach. In this perspective, we formulate ten major questions regarding the use of GCs in critical illness. Answering them will likely facilitate a new era of effective and personalized GCs use in modern critical care.
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spelling pubmed-95476742022-10-10 Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions Winkler, Martin S. Osuchowski, Marcin F. Payen, Didier Torres, Antoni Dickel, Steffen Skirecki, Tomasz Crit Care Perspective The 40-year-old experience with glucocorticosteroids (GCs) in the context of severe infections is complex and troublesome. Recently, however, a clear indication for GCs in severe COVID-19 has been established. This may constitute a harbinger of a wider use of GCs in critical illnesses. A fundamental prerequisite of such an action is a better understanding of the heterogeneity of critical illness and GCs operationalization within the precision medicine approach. In this perspective, we formulate ten major questions regarding the use of GCs in critical illness. Answering them will likely facilitate a new era of effective and personalized GCs use in modern critical care. BioMed Central 2022-10-08 /pmc/articles/PMC9547674/ /pubmed/36209188 http://dx.doi.org/10.1186/s13054-022-04185-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Perspective
Winkler, Martin S.
Osuchowski, Marcin F.
Payen, Didier
Torres, Antoni
Dickel, Steffen
Skirecki, Tomasz
Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions
title Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions
title_full Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions
title_fullStr Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions
title_full_unstemmed Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions
title_short Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions
title_sort renaissance of glucocorticoids in critical care in the era of covid-19: ten urging questions
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547674/
https://www.ncbi.nlm.nih.gov/pubmed/36209188
http://dx.doi.org/10.1186/s13054-022-04185-9
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