Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities

Myasthenia gravis is an autoimmune disorder defined by muscle weakness and fatigability associated with antibodies against proteins of the neuromuscular junction (NMJ). The most common autoantibody target is the acetylcholine receptor (AChR). Three mechanisms have been postulated by which autoantibo...

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Detalles Bibliográficos
Autores principales: Rose, Natalie, Holdermann, Sebastian, Callegari, Ilaria, Kim, Hyein, Fruh, Isabelle, Kappos, Ludwig, Kuhle, Jens, Müller, Matthias, Sanderson, Nicholas S. R., Derfuss, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547806/
https://www.ncbi.nlm.nih.gov/pubmed/36074148
http://dx.doi.org/10.1007/s00401-022-02493-6

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