A CHCHD6–APP axis connects amyloid and mitochondrial pathology in Alzheimer’s disease

The mechanistic relationship between amyloid-beta precursor protein (APP) processing and mitochondrial dysfunction in Alzheimer’s disease (AD) has long eluded the field. Here, we report that coiled-coil-helix-coiled-coil-helix domain containing 6 (CHCHD6), a core protein of the mammalian mitochondri...

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Detalles Bibliográficos
Autores principales: Shang, Yutong, Sun, Xiaoyan, Chen, Xiaoqin, Wang, Quanqiu, Wang, Evan J., Miller, Emiko, Xu, Rong, Pieper, Andrew A., Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547808/
https://www.ncbi.nlm.nih.gov/pubmed/36104602
http://dx.doi.org/10.1007/s00401-022-02499-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547808/
https://www.ncbi.nlm.nih.gov/pubmed/36104602
http://dx.doi.org/10.1007/s00401-022-02499-0

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