PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD

ER stress signaling is linked to the pathophysiological and clinical disease manifestations in amyotrophic lateral sclerosis (ALS). Here, we have investigated ER stress-induced adaptive mechanisms in C9ORF72-ALS/FTD, focusing on uncovering early endogenous neuroprotective mechanisms and the crosstal...

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Detalles Bibliográficos
Autores principales: Pilotto, Federica, Schmitz, Alexander, Maharjan, Niran, Diab, Rim, Odriozola, Adolfo, Tripathi, Priyanka, Yamoah, Alfred, Scheidegger, Olivier, Oestmann, Angelina, Dennys, Cassandra N., Sinha Ray, Shrestha, Rodrigo, Rochelle, Kolb, Stephen, Aronica, Eleonora, Di Santo, Stefano, Widmer, Hans Rudolf, Charlet-Berguerand, Nicolas, Selvaraj, Bhuvaneish T, Chandran, Siddharthan, Meyer, Kathrin, Zuber, Benoît, Goswami, Anand, Weis, Joachim, Saxena, Smita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547809/
https://www.ncbi.nlm.nih.gov/pubmed/36121477
http://dx.doi.org/10.1007/s00401-022-02494-5

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