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The determination of the effect(s) of solute carrier family 22-member 2 (SLC22A2) haplotype variants on drug binding via molecular dynamic simulation systems

Single nucleotide polymorphisms detected in the solute carrier member family-22 has been shown to result in a variable response in the treatment of type 2 diabetes mellitus with Metformin. This study predicted a three-dimensional protein structure for the SLC22A2 protein sequence using AlphaFold 2 a...

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Detalles Bibliográficos
Autores principales:	Abrahams-October, Zainonesa, Johnson, Rabia, Benjeddou, Mongi, Cloete, Ruben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547889/ https://www.ncbi.nlm.nih.gov/pubmed/36209293 http://dx.doi.org/10.1038/s41598-022-21291-4

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