PLEKHH2 binds β-arrestin1 through its FERM domain, activates FAK/PI3K/AKT phosphorylation, and promotes the malignant phenotype of non-small cell lung cancer

PLEKHH2 is an important FERM domain containing-protein. However, the role of PLEKHH2 in human solid tumors has not been reported yet. We report that PLEKHH2 showed enhanced cytoplasmic expression in non-small cell lung cancer (NSCLC). Its overexpression was positively correlated with high TNM stage,...

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Detalles Bibliográficos
Autores principales: Wang, Rui, Wang, Si, Li, Zhen, Luo, Yuan, Zhao, Yue, Han, Qiang, Rong, Xue-Zhu, Guo, Yao-Xing, Liu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547923/
https://www.ncbi.nlm.nih.gov/pubmed/36209201
http://dx.doi.org/10.1038/s41419-022-05307-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547923/
https://www.ncbi.nlm.nih.gov/pubmed/36209201
http://dx.doi.org/10.1038/s41419-022-05307-5

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