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Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation

Racial/ethnic disparities persist in patients' access to living donor kidney transplantation (LDKT). This study assessed the impact of having available potential living donors (PLDs) on candidates' receipt of a kidney transplant (KT) and LDKT at two KT programs. Using data from our clinica...

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Autores principales: Gordon, Elisa J., Lee, Jungwha, Kang, Raymond, Caicedo, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547969/
https://www.ncbi.nlm.nih.gov/pubmed/35524363
http://dx.doi.org/10.1111/ajt.17090
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author Gordon, Elisa J.
Lee, Jungwha
Kang, Raymond
Caicedo, Juan Carlos
author_facet Gordon, Elisa J.
Lee, Jungwha
Kang, Raymond
Caicedo, Juan Carlos
author_sort Gordon, Elisa J.
collection PubMed
description Racial/ethnic disparities persist in patients' access to living donor kidney transplantation (LDKT). This study assessed the impact of having available potential living donors (PLDs) on candidates' receipt of a kidney transplant (KT) and LDKT at two KT programs. Using data from our clinical trial of waitlisted candidates (January 1, 2014–December 31, 2019), we evaluated Hispanic and Non‐Hispanic White (NHW) KT candidates' number of PLDs. Multivariable logistic regression assessed the impact of PLDs on transplantation (KT vs. no KT; for KT recipients, LDKT vs. deceased donor KT). A total of 847 candidates were included, identifying as Hispanic (45.8%) or NHW (54.2%). For Site A, both Hispanic (adjusted OR = 2.26 [95% CI 1.13–4.53]) and NHW (OR = 2.42 [1.10–5.33]) candidates with PLDs completing the questionnaire were more likely to receive a KT. For Site B, candidates with PLDs were not significantly more likely to receive KT. Among KT recipients at both sites, Hispanic (Site A: OR = 21.22 [2.44–184.88]; Site B: OR = 25.54 [7.52–101.54]), and NHW (Site A: OR = 37.70 [6.59–215.67]; Site B: OR = 15.18 [5.64–40.85]) recipients with PLD(s) were significantly more likely to receive a LDKT. Our findings suggest that PLDs increased candidates' likelihood of KT receipt, particularly LDKT. Transplant programs should help candidates identify PLDs early in transplant evaluation.
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spelling pubmed-95479692022-12-28 Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation Gordon, Elisa J. Lee, Jungwha Kang, Raymond Caicedo, Juan Carlos Am J Transplant Brief Communications Racial/ethnic disparities persist in patients' access to living donor kidney transplantation (LDKT). This study assessed the impact of having available potential living donors (PLDs) on candidates' receipt of a kidney transplant (KT) and LDKT at two KT programs. Using data from our clinical trial of waitlisted candidates (January 1, 2014–December 31, 2019), we evaluated Hispanic and Non‐Hispanic White (NHW) KT candidates' number of PLDs. Multivariable logistic regression assessed the impact of PLDs on transplantation (KT vs. no KT; for KT recipients, LDKT vs. deceased donor KT). A total of 847 candidates were included, identifying as Hispanic (45.8%) or NHW (54.2%). For Site A, both Hispanic (adjusted OR = 2.26 [95% CI 1.13–4.53]) and NHW (OR = 2.42 [1.10–5.33]) candidates with PLDs completing the questionnaire were more likely to receive a KT. For Site B, candidates with PLDs were not significantly more likely to receive KT. Among KT recipients at both sites, Hispanic (Site A: OR = 21.22 [2.44–184.88]; Site B: OR = 25.54 [7.52–101.54]), and NHW (Site A: OR = 37.70 [6.59–215.67]; Site B: OR = 15.18 [5.64–40.85]) recipients with PLD(s) were significantly more likely to receive a LDKT. Our findings suggest that PLDs increased candidates' likelihood of KT receipt, particularly LDKT. Transplant programs should help candidates identify PLDs early in transplant evaluation. John Wiley and Sons Inc. 2022-05-24 2022-10 /pmc/articles/PMC9547969/ /pubmed/35524363 http://dx.doi.org/10.1111/ajt.17090 Text en © 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Gordon, Elisa J.
Lee, Jungwha
Kang, Raymond
Caicedo, Juan Carlos
Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation
title Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation
title_full Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation
title_fullStr Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation
title_full_unstemmed Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation
title_short Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation
title_sort impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547969/
https://www.ncbi.nlm.nih.gov/pubmed/35524363
http://dx.doi.org/10.1111/ajt.17090
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