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Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Huntington’s disease (HD) is a neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein encoded from extra tracts of CAG repeats in exon 1 of the HTT gene. mHTT proteins are neurotoxic to render the death of neurons and a series of disease-associated phenotypes. The m...

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Detalles Bibliográficos
Autores principales:	Long, Jiahui, Luo, Xia, Fang, Dongmei, Song, Haikun, Fang, Weibin, Shan, Hao, Liu, Peiqing, Lu, Boxun, Yin, Xiao-Ming, Hong, Liang, Li, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548129/ https://www.ncbi.nlm.nih.gov/pubmed/36209136 http://dx.doi.org/10.1186/s13578-022-00906-3

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