Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia

Production of peste des petits ruminants (PPR) vaccines in Russia is based on two attenuated virus strains (“45G37/35-k” and “ARRIAH”) of common origin. Here, the identity of the strain PPRV/45G37/35-k was investigated using a full genome, Illumina deep sequencing approach. Phylogenomic analysis sho...

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Detalles Bibliográficos
Autores principales: Kwiatek, Olivier, Libeau, Geneviève, Guendouz, Samia, Corbanini, Chloé, Gogin, Andrey, Lunitsin, Andrey, Sindryakova, Irina, Koblasov, Denis, Bataille, Arnaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548208/
https://www.ncbi.nlm.nih.gov/pubmed/36209143
http://dx.doi.org/10.1186/s13567-022-01099-w
Descripción
Sumario:Production of peste des petits ruminants (PPR) vaccines in Russia is based on two attenuated virus strains (“45G37/35-k” and “ARRIAH”) of common origin. Here, the identity of the strain PPRV/45G37/35-k was investigated using a full genome, Illumina deep sequencing approach. Phylogenomic analysis showed that PPRV/45G37/35-k belongs to the same lineage as the widely used PPRV vaccine strain Nigeria/75/1 (lineage II). However, 248 nucleotide differences separate the genomes of these vaccine strains, indicating that the PPRV vaccine strains produced in Russia are new strains not yet recognised by the World Organization for Animal Health (WOAH). Detailed information on the safety and efficacy of these vaccines should be provided to the WOAH before further national and international distribution. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-022-01099-w.

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