Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia

Production of peste des petits ruminants (PPR) vaccines in Russia is based on two attenuated virus strains (“45G37/35-k” and “ARRIAH”) of common origin. Here, the identity of the strain PPRV/45G37/35-k was investigated using a full genome, Illumina deep sequencing approach. Phylogenomic analysis sho...

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Autores principales: Kwiatek, Olivier, Libeau, Geneviève, Guendouz, Samia, Corbanini, Chloé, Gogin, Andrey, Lunitsin, Andrey, Sindryakova, Irina, Koblasov, Denis, Bataille, Arnaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548208/
https://www.ncbi.nlm.nih.gov/pubmed/36209143
http://dx.doi.org/10.1186/s13567-022-01099-w
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author Kwiatek, Olivier
Libeau, Geneviève
Guendouz, Samia
Corbanini, Chloé
Gogin, Andrey
Lunitsin, Andrey
Sindryakova, Irina
Koblasov, Denis
Bataille, Arnaud
author_facet Kwiatek, Olivier
Libeau, Geneviève
Guendouz, Samia
Corbanini, Chloé
Gogin, Andrey
Lunitsin, Andrey
Sindryakova, Irina
Koblasov, Denis
Bataille, Arnaud
author_sort Kwiatek, Olivier
collection PubMed
description Production of peste des petits ruminants (PPR) vaccines in Russia is based on two attenuated virus strains (“45G37/35-k” and “ARRIAH”) of common origin. Here, the identity of the strain PPRV/45G37/35-k was investigated using a full genome, Illumina deep sequencing approach. Phylogenomic analysis showed that PPRV/45G37/35-k belongs to the same lineage as the widely used PPRV vaccine strain Nigeria/75/1 (lineage II). However, 248 nucleotide differences separate the genomes of these vaccine strains, indicating that the PPRV vaccine strains produced in Russia are new strains not yet recognised by the World Organization for Animal Health (WOAH). Detailed information on the safety and efficacy of these vaccines should be provided to the WOAH before further national and international distribution. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-022-01099-w.
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spelling pubmed-95482082022-10-10 Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia Kwiatek, Olivier Libeau, Geneviève Guendouz, Samia Corbanini, Chloé Gogin, Andrey Lunitsin, Andrey Sindryakova, Irina Koblasov, Denis Bataille, Arnaud Vet Res Short Report Production of peste des petits ruminants (PPR) vaccines in Russia is based on two attenuated virus strains (“45G37/35-k” and “ARRIAH”) of common origin. Here, the identity of the strain PPRV/45G37/35-k was investigated using a full genome, Illumina deep sequencing approach. Phylogenomic analysis showed that PPRV/45G37/35-k belongs to the same lineage as the widely used PPRV vaccine strain Nigeria/75/1 (lineage II). However, 248 nucleotide differences separate the genomes of these vaccine strains, indicating that the PPRV vaccine strains produced in Russia are new strains not yet recognised by the World Organization for Animal Health (WOAH). Detailed information on the safety and efficacy of these vaccines should be provided to the WOAH before further national and international distribution. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-022-01099-w. BioMed Central 2022-10-08 2022 /pmc/articles/PMC9548208/ /pubmed/36209143 http://dx.doi.org/10.1186/s13567-022-01099-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Kwiatek, Olivier
Libeau, Geneviève
Guendouz, Samia
Corbanini, Chloé
Gogin, Andrey
Lunitsin, Andrey
Sindryakova, Irina
Koblasov, Denis
Bataille, Arnaud
Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia
title Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia
title_full Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia
title_fullStr Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia
title_full_unstemmed Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia
title_short Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia
title_sort genomic characterization of peste des petits ruminants vaccine seed “45g37/35-k”, russia
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548208/
https://www.ncbi.nlm.nih.gov/pubmed/36209143
http://dx.doi.org/10.1186/s13567-022-01099-w
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