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Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic

BACKGROUND AND OBJECTIVE: The COVID-19 pandemic negatively impacted the well-being of persons with neuroinflammatory diseases (pwNID). Identifying factors that influence the response to challenging conditions could guide supportive care. METHODS: 2185 pwNID and 1079 healthy controls (HCs) from five...

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Autores principales: Jakimovski, Dejan, Kavak, Katelyn S, Longbrake, Erin E., Levit, Elle, Perrone, Christopher M, Bar-Or, Amit, Benedict, Ralph HB, Riley, Claire S, De Jager, Philip L, Venkatesh, Shruthi, Walker, Elizabeth L.S., Xia, Zongqi, Weinstock-Guttman, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548342/
https://www.ncbi.nlm.nih.gov/pubmed/36283322
http://dx.doi.org/10.1016/j.msard.2022.104235
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author Jakimovski, Dejan
Kavak, Katelyn S
Longbrake, Erin E.
Levit, Elle
Perrone, Christopher M
Bar-Or, Amit
Benedict, Ralph HB
Riley, Claire S
De Jager, Philip L
Venkatesh, Shruthi
Walker, Elizabeth L.S.
Xia, Zongqi
Weinstock-Guttman, Bianca
author_facet Jakimovski, Dejan
Kavak, Katelyn S
Longbrake, Erin E.
Levit, Elle
Perrone, Christopher M
Bar-Or, Amit
Benedict, Ralph HB
Riley, Claire S
De Jager, Philip L
Venkatesh, Shruthi
Walker, Elizabeth L.S.
Xia, Zongqi
Weinstock-Guttman, Bianca
author_sort Jakimovski, Dejan
collection PubMed
description BACKGROUND AND OBJECTIVE: The COVID-19 pandemic negatively impacted the well-being of persons with neuroinflammatory diseases (pwNID). Identifying factors that influence the response to challenging conditions could guide supportive care. METHODS: 2185 pwNID and 1079 healthy controls (HCs) from five US centers completed an online survey regarding the effects of the COVID-19 pandemic on physical and psychological well-being. Survey instruments included resilience (Connor-Davidson Resilience Scale, CD-RISC), loneliness (UCLA Loneliness Scale), social support (modified social support survey, MSSS-5), personality traits (NEO-Five Factor Inventory, NEO-FFI), and disability (Patient-Determined Disability Steps (PDDS). Step-wise regression models and mediation analyses assessed whether the level of self-reported resilience, size of the social support, and specific personality traits (study predictors) were associated with self-reported disability and/or loneliness (study outcomes). RESULTS: The response rate varied significantly between the questionnaires. While, all pwNID completed the demographic questionnaire, 78.8% completed the loneliness questionnaire and 49.7% completed the NEO-FFI. Based on 787 responses, greater neuroticism (standardized β = 0.312, p < 0.001), less social support (standardized β = -0.242, p < 0.001), lower extraversion (standardized β = -0.083, p=0.017), lower agreeableness (standardized β = -0.119, p < 0.001), and lower resilience (standardized β = -0.125, p = 0.002) were associated with the feeling of loneliness. Social support and resilience modestly but significantly mediated the association between personality traits and loneliness. Older age (standardized β = 0.165, p < 0.001) and lower conscientiousness (standardized β = -0.094, p = 0.007) were associated with worse disability (higher PDDS scores). There were no differences in outcomes between pwNID and HCs. CONCLUSION: Greater social support potentially attenuates the association between neuroticism and the feeling of loneliness in pwNID during the COVID-19 pandemic. Assessment of personality traits may identify pwNID that are in greater need of social support and guide targeted interventions.
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spelling pubmed-95483422022-10-11 Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic Jakimovski, Dejan Kavak, Katelyn S Longbrake, Erin E. Levit, Elle Perrone, Christopher M Bar-Or, Amit Benedict, Ralph HB Riley, Claire S De Jager, Philip L Venkatesh, Shruthi Walker, Elizabeth L.S. Xia, Zongqi Weinstock-Guttman, Bianca Mult Scler Relat Disord Original Article BACKGROUND AND OBJECTIVE: The COVID-19 pandemic negatively impacted the well-being of persons with neuroinflammatory diseases (pwNID). Identifying factors that influence the response to challenging conditions could guide supportive care. METHODS: 2185 pwNID and 1079 healthy controls (HCs) from five US centers completed an online survey regarding the effects of the COVID-19 pandemic on physical and psychological well-being. Survey instruments included resilience (Connor-Davidson Resilience Scale, CD-RISC), loneliness (UCLA Loneliness Scale), social support (modified social support survey, MSSS-5), personality traits (NEO-Five Factor Inventory, NEO-FFI), and disability (Patient-Determined Disability Steps (PDDS). Step-wise regression models and mediation analyses assessed whether the level of self-reported resilience, size of the social support, and specific personality traits (study predictors) were associated with self-reported disability and/or loneliness (study outcomes). RESULTS: The response rate varied significantly between the questionnaires. While, all pwNID completed the demographic questionnaire, 78.8% completed the loneliness questionnaire and 49.7% completed the NEO-FFI. Based on 787 responses, greater neuroticism (standardized β = 0.312, p < 0.001), less social support (standardized β = -0.242, p < 0.001), lower extraversion (standardized β = -0.083, p=0.017), lower agreeableness (standardized β = -0.119, p < 0.001), and lower resilience (standardized β = -0.125, p = 0.002) were associated with the feeling of loneliness. Social support and resilience modestly but significantly mediated the association between personality traits and loneliness. Older age (standardized β = 0.165, p < 0.001) and lower conscientiousness (standardized β = -0.094, p = 0.007) were associated with worse disability (higher PDDS scores). There were no differences in outcomes between pwNID and HCs. CONCLUSION: Greater social support potentially attenuates the association between neuroticism and the feeling of loneliness in pwNID during the COVID-19 pandemic. Assessment of personality traits may identify pwNID that are in greater need of social support and guide targeted interventions. Elsevier B.V. 2022-12 2022-10-09 /pmc/articles/PMC9548342/ /pubmed/36283322 http://dx.doi.org/10.1016/j.msard.2022.104235 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Jakimovski, Dejan
Kavak, Katelyn S
Longbrake, Erin E.
Levit, Elle
Perrone, Christopher M
Bar-Or, Amit
Benedict, Ralph HB
Riley, Claire S
De Jager, Philip L
Venkatesh, Shruthi
Walker, Elizabeth L.S.
Xia, Zongqi
Weinstock-Guttman, Bianca
Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic
title Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic
title_full Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic
title_fullStr Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic
title_full_unstemmed Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic
title_short Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic
title_sort impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the covid-19 pandemic
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548342/
https://www.ncbi.nlm.nih.gov/pubmed/36283322
http://dx.doi.org/10.1016/j.msard.2022.104235
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