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Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis

The APOE-ε4 allele is known to predispose to amyloid deposition and consequently is strongly associated with Alzheimer's disease (AD) risk. There is debate as to whether the APOE gene accounts for all genetic variation of the APOE locus. Another question which remains is whether APOE-ε4 carrier...

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Detalles Bibliográficos
Autores principales:	Bracher-Smith, Matthew, Leonenko, Ganna, Baker, Emily, Crawford, Karen, Graham, Andrew C., Salih, Dervis A., Howell, Brian W., Hardy, John, Escott-Price, Valentina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548409/ https://www.ncbi.nlm.nih.gov/pubmed/35977442 http://dx.doi.org/10.1016/j.neurobiolaging.2022.07.009

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