The emerging role of long non-coding RNAs in schizophrenia

Schizophrenia (SZ) is a severe psychiatric disorder which is contributed by both genetic and environmental factors. However, at present, its specific pathogenesis is still not very clear, and there is a lack of objective and reliable biomarkers. Accumulating evidence indicates that long non-coding R...

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Autores principales: Wu, Guangxian, Du, Xinzhe, Li, Zexuan, Du, Yanhong, Lv, Jinzhi, Li, Xinrong, Xu, Yong, Liu, Sha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548578/
https://www.ncbi.nlm.nih.gov/pubmed/36226104
http://dx.doi.org/10.3389/fpsyt.2022.995956
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author Wu, Guangxian
Du, Xinzhe
Li, Zexuan
Du, Yanhong
Lv, Jinzhi
Li, Xinrong
Xu, Yong
Liu, Sha
author_facet Wu, Guangxian
Du, Xinzhe
Li, Zexuan
Du, Yanhong
Lv, Jinzhi
Li, Xinrong
Xu, Yong
Liu, Sha
author_sort Wu, Guangxian
collection PubMed
description Schizophrenia (SZ) is a severe psychiatric disorder which is contributed by both genetic and environmental factors. However, at present, its specific pathogenesis is still not very clear, and there is a lack of objective and reliable biomarkers. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involved in the pathophysiology of several psychiatric disorders, including SZ, and hold promise as potential biomarkers and therapeutic targets for psychiatric disorders. In this review, we summarize and discuss the role of lncRNAs in the pathogenesis of SZ and their potential value as biomarkers and therapeutic targets.
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spelling pubmed-95485782022-10-11 The emerging role of long non-coding RNAs in schizophrenia Wu, Guangxian Du, Xinzhe Li, Zexuan Du, Yanhong Lv, Jinzhi Li, Xinrong Xu, Yong Liu, Sha Front Psychiatry Psychiatry Schizophrenia (SZ) is a severe psychiatric disorder which is contributed by both genetic and environmental factors. However, at present, its specific pathogenesis is still not very clear, and there is a lack of objective and reliable biomarkers. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involved in the pathophysiology of several psychiatric disorders, including SZ, and hold promise as potential biomarkers and therapeutic targets for psychiatric disorders. In this review, we summarize and discuss the role of lncRNAs in the pathogenesis of SZ and their potential value as biomarkers and therapeutic targets. Frontiers Media S.A. 2022-09-26 /pmc/articles/PMC9548578/ /pubmed/36226104 http://dx.doi.org/10.3389/fpsyt.2022.995956 Text en Copyright © 2022 Wu, Du, Li, Du, Lv, Li, Xu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Wu, Guangxian
Du, Xinzhe
Li, Zexuan
Du, Yanhong
Lv, Jinzhi
Li, Xinrong
Xu, Yong
Liu, Sha
The emerging role of long non-coding RNAs in schizophrenia
title The emerging role of long non-coding RNAs in schizophrenia
title_full The emerging role of long non-coding RNAs in schizophrenia
title_fullStr The emerging role of long non-coding RNAs in schizophrenia
title_full_unstemmed The emerging role of long non-coding RNAs in schizophrenia
title_short The emerging role of long non-coding RNAs in schizophrenia
title_sort emerging role of long non-coding rnas in schizophrenia
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548578/
https://www.ncbi.nlm.nih.gov/pubmed/36226104
http://dx.doi.org/10.3389/fpsyt.2022.995956
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