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Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline

BACKGROUND: Prenatal and early postnatal choline supplementation reduces cognitive and behavioral deficits in animal models of Fetal Alcohol Spectrum Disorder (FASD). In a previously published 9-month clinical trial of choline supplementation in children with FASD, we reported that postnatal choline...

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Autores principales: Fuglestad, Anita J., Miller, Neely C., Fink, Birgit A., Boys, Christopher J., Eckerle, Judith K., Georgieff, Michael K., Wozniak, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548619/
https://www.ncbi.nlm.nih.gov/pubmed/36225707
http://dx.doi.org/10.3389/fpsyg.2022.936019
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author Fuglestad, Anita J.
Miller, Neely C.
Fink, Birgit A.
Boys, Christopher J.
Eckerle, Judith K.
Georgieff, Michael K.
Wozniak, Jeffrey R.
author_facet Fuglestad, Anita J.
Miller, Neely C.
Fink, Birgit A.
Boys, Christopher J.
Eckerle, Judith K.
Georgieff, Michael K.
Wozniak, Jeffrey R.
author_sort Fuglestad, Anita J.
collection PubMed
description BACKGROUND: Prenatal and early postnatal choline supplementation reduces cognitive and behavioral deficits in animal models of Fetal Alcohol Spectrum Disorder (FASD). In a previously published 9-month clinical trial of choline supplementation in children with FASD, we reported that postnatal choline was associated with improved performance on a hippocampal-dependent recognition memory task. The current paper describes the neurophysiological correlates of that memory performance for trial completers. METHODS: Children with FASD (N = 24) who were enrolled in a clinical trial of choline supplementation were followed for 9 months. Delayed recall on a 9-step elicited imitation task (EI) served as the behavioral measure of recognition memory. Neurophysiological correlates of memory were assessed via event-related potentials (ERP). RESULTS: Delayed recall on EI was correlated with two ERP components commonly associated with recognition memory in young children: middle latency negative component (Nc amplitude; range: r = −0.41 to r = −0.44) and positive slow wave (PSW area under the curve; range: r = −0.45 to r = −0.63). No significant ERP differences were observed between the choline and placebo groups at the conclusion of the trial. CONCLUSION: Although the small sample size limits the ability to draw clear conclusions about the treatment effect of choline on ERP, the results suggest a relationship between memory performance and underlying neurophysiological status in FASD. This trial was registered.
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spelling pubmed-95486192022-10-11 Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline Fuglestad, Anita J. Miller, Neely C. Fink, Birgit A. Boys, Christopher J. Eckerle, Judith K. Georgieff, Michael K. Wozniak, Jeffrey R. Front Psychol Psychology BACKGROUND: Prenatal and early postnatal choline supplementation reduces cognitive and behavioral deficits in animal models of Fetal Alcohol Spectrum Disorder (FASD). In a previously published 9-month clinical trial of choline supplementation in children with FASD, we reported that postnatal choline was associated with improved performance on a hippocampal-dependent recognition memory task. The current paper describes the neurophysiological correlates of that memory performance for trial completers. METHODS: Children with FASD (N = 24) who were enrolled in a clinical trial of choline supplementation were followed for 9 months. Delayed recall on a 9-step elicited imitation task (EI) served as the behavioral measure of recognition memory. Neurophysiological correlates of memory were assessed via event-related potentials (ERP). RESULTS: Delayed recall on EI was correlated with two ERP components commonly associated with recognition memory in young children: middle latency negative component (Nc amplitude; range: r = −0.41 to r = −0.44) and positive slow wave (PSW area under the curve; range: r = −0.45 to r = −0.63). No significant ERP differences were observed between the choline and placebo groups at the conclusion of the trial. CONCLUSION: Although the small sample size limits the ability to draw clear conclusions about the treatment effect of choline on ERP, the results suggest a relationship between memory performance and underlying neurophysiological status in FASD. This trial was registered. Frontiers Media S.A. 2022-09-26 /pmc/articles/PMC9548619/ /pubmed/36225707 http://dx.doi.org/10.3389/fpsyg.2022.936019 Text en Copyright © 2022 Fuglestad, Miller, Fink, Boys, Eckerle, Georgieff and Wozniak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Fuglestad, Anita J.
Miller, Neely C.
Fink, Birgit A.
Boys, Christopher J.
Eckerle, Judith K.
Georgieff, Michael K.
Wozniak, Jeffrey R.
Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline
title Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline
title_full Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline
title_fullStr Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline
title_full_unstemmed Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline
title_short Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline
title_sort neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548619/
https://www.ncbi.nlm.nih.gov/pubmed/36225707
http://dx.doi.org/10.3389/fpsyg.2022.936019
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