Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency

We report a case of immune reconstitution inflammatory syndrome (IRIS) after hematopoietic stem cell transplantation (HSCT). The patient had sever bacillus Calmette–Guerin (BCG) vaccine–caused disseminated infection and had received allogeneic HSCT for X-linked severe combined immunodeficiency disea...

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Autores principales: Liu, Shuangjun, Huo, Feng, Dai, Guorui, Wu, Jie, Qin, Maoquan, Mao, Huawei, Wang, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548620/
https://www.ncbi.nlm.nih.gov/pubmed/36225916
http://dx.doi.org/10.3389/fimmu.2022.960749
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author Liu, Shuangjun
Huo, Feng
Dai, Guorui
Wu, Jie
Qin, Maoquan
Mao, Huawei
Wang, Quan
author_facet Liu, Shuangjun
Huo, Feng
Dai, Guorui
Wu, Jie
Qin, Maoquan
Mao, Huawei
Wang, Quan
author_sort Liu, Shuangjun
collection PubMed
description We report a case of immune reconstitution inflammatory syndrome (IRIS) after hematopoietic stem cell transplantation (HSCT). The patient had sever bacillus Calmette–Guerin (BCG) vaccine–caused disseminated infection and had received allogeneic HSCT for X-linked severe combined immunodeficiency disease. After HSCT, complicated by treatment-responding veno-occlusive disease and acute graft-versus-host disease, at the time when immunosuppressants were withdrawn, the patient experienced recurrent fever accompanied by elevated inflammatory indicators. After receiving glucocorticoids and ibuprofen, the patient’s condition improved, and a diagnosis with BCG-related IRIS was made.
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spelling pubmed-95486202022-10-11 Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency Liu, Shuangjun Huo, Feng Dai, Guorui Wu, Jie Qin, Maoquan Mao, Huawei Wang, Quan Front Immunol Immunology We report a case of immune reconstitution inflammatory syndrome (IRIS) after hematopoietic stem cell transplantation (HSCT). The patient had sever bacillus Calmette–Guerin (BCG) vaccine–caused disseminated infection and had received allogeneic HSCT for X-linked severe combined immunodeficiency disease. After HSCT, complicated by treatment-responding veno-occlusive disease and acute graft-versus-host disease, at the time when immunosuppressants were withdrawn, the patient experienced recurrent fever accompanied by elevated inflammatory indicators. After receiving glucocorticoids and ibuprofen, the patient’s condition improved, and a diagnosis with BCG-related IRIS was made. Frontiers Media S.A. 2022-09-26 /pmc/articles/PMC9548620/ /pubmed/36225916 http://dx.doi.org/10.3389/fimmu.2022.960749 Text en Copyright © 2022 Liu, Huo, Dai, Wu, Qin, Mao and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Shuangjun
Huo, Feng
Dai, Guorui
Wu, Jie
Qin, Maoquan
Mao, Huawei
Wang, Quan
Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency
title Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency
title_full Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency
title_fullStr Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency
title_full_unstemmed Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency
title_short Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency
title_sort case report: immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548620/
https://www.ncbi.nlm.nih.gov/pubmed/36225916
http://dx.doi.org/10.3389/fimmu.2022.960749
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