Cargando…
Age-specific association between non-HDL-C and arterial stiffness in the Chinese population
BACKGROUND: While some epidemiological studies have found correlations between non-high-density lipoprotein cholesterol (non-HDL-C) and arterial stiffness, there are still exist controversial and age-stratified analysis are scarce yet. METHODS: All individuals in this study were recruited in the Thi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548648/ https://www.ncbi.nlm.nih.gov/pubmed/36225964 http://dx.doi.org/10.3389/fcvm.2022.981028 |
_version_ | 1784805478606307328 |
---|---|
author | Wang, Jie Miao, Rujia Chen, Zhiheng Wang, Jiangang Yuan, Hong Li, Jing Huang, Zheng |
author_facet | Wang, Jie Miao, Rujia Chen, Zhiheng Wang, Jiangang Yuan, Hong Li, Jing Huang, Zheng |
author_sort | Wang, Jie |
collection | PubMed |
description | BACKGROUND: While some epidemiological studies have found correlations between non-high-density lipoprotein cholesterol (non-HDL-C) and arterial stiffness, there are still exist controversial and age-stratified analysis are scarce yet. METHODS: All individuals in this study were recruited in the Third Xiangya Hospital of Central South University from 2012 to 2016. Arterial stiffness was defined as brachial-ankle pulse wave velocity (baPWV) ≥1,400 cm/s. Association between non-HDL-C and arterial stiffness were explored using Cox proportional-hazards model. We also conducted subanalysis stratified by age. Furthermore, restricted cubic splines were used to model exposure-response relationships in cohort sample. RESULTS: This cohort study included 7,276 participants without arterial stiffness at baseline. Over a median follow-up of 1.78 years (IQR, 1.03–2.49), 1,669 participants have identified with incident arterial stiffness. In multivariable-adjusted analyses, higher non-HDL-C concentration was associated with incident arterial stiffness with an adjusted hazard ratio (HR) of 1.09 [95% confidence interval (CI), 1.02–1.17] per 1 mmol/L increase. Compared with the lowest tertile, the HR for arterial stiffness with respect to the highest tertile of non-HDL-C was 1.26 (95% CI, 1.07–1.48). The results were similar in the analysis of young participants (age <60 years). CONCLUSION: Our study identified that non-HDL-C as a potential risk factor of arterial stiffness, especially for younger. The clinical benefits of decreasing non-HDL-C concentration should be further considered in the future. |
format | Online Article Text |
id | pubmed-9548648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95486482022-10-11 Age-specific association between non-HDL-C and arterial stiffness in the Chinese population Wang, Jie Miao, Rujia Chen, Zhiheng Wang, Jiangang Yuan, Hong Li, Jing Huang, Zheng Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: While some epidemiological studies have found correlations between non-high-density lipoprotein cholesterol (non-HDL-C) and arterial stiffness, there are still exist controversial and age-stratified analysis are scarce yet. METHODS: All individuals in this study were recruited in the Third Xiangya Hospital of Central South University from 2012 to 2016. Arterial stiffness was defined as brachial-ankle pulse wave velocity (baPWV) ≥1,400 cm/s. Association between non-HDL-C and arterial stiffness were explored using Cox proportional-hazards model. We also conducted subanalysis stratified by age. Furthermore, restricted cubic splines were used to model exposure-response relationships in cohort sample. RESULTS: This cohort study included 7,276 participants without arterial stiffness at baseline. Over a median follow-up of 1.78 years (IQR, 1.03–2.49), 1,669 participants have identified with incident arterial stiffness. In multivariable-adjusted analyses, higher non-HDL-C concentration was associated with incident arterial stiffness with an adjusted hazard ratio (HR) of 1.09 [95% confidence interval (CI), 1.02–1.17] per 1 mmol/L increase. Compared with the lowest tertile, the HR for arterial stiffness with respect to the highest tertile of non-HDL-C was 1.26 (95% CI, 1.07–1.48). The results were similar in the analysis of young participants (age <60 years). CONCLUSION: Our study identified that non-HDL-C as a potential risk factor of arterial stiffness, especially for younger. The clinical benefits of decreasing non-HDL-C concentration should be further considered in the future. Frontiers Media S.A. 2022-09-26 /pmc/articles/PMC9548648/ /pubmed/36225964 http://dx.doi.org/10.3389/fcvm.2022.981028 Text en Copyright © 2022 Wang, Miao, Chen, Wang, Yuan, Li and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Wang, Jie Miao, Rujia Chen, Zhiheng Wang, Jiangang Yuan, Hong Li, Jing Huang, Zheng Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
title | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
title_full | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
title_fullStr | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
title_full_unstemmed | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
title_short | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
title_sort | age-specific association between non-hdl-c and arterial stiffness in the chinese population |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548648/ https://www.ncbi.nlm.nih.gov/pubmed/36225964 http://dx.doi.org/10.3389/fcvm.2022.981028 |
work_keys_str_mv | AT wangjie agespecificassociationbetweennonhdlcandarterialstiffnessinthechinesepopulation AT miaorujia agespecificassociationbetweennonhdlcandarterialstiffnessinthechinesepopulation AT chenzhiheng agespecificassociationbetweennonhdlcandarterialstiffnessinthechinesepopulation AT wangjiangang agespecificassociationbetweennonhdlcandarterialstiffnessinthechinesepopulation AT yuanhong agespecificassociationbetweennonhdlcandarterialstiffnessinthechinesepopulation AT lijing agespecificassociationbetweennonhdlcandarterialstiffnessinthechinesepopulation AT huangzheng agespecificassociationbetweennonhdlcandarterialstiffnessinthechinesepopulation |