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Structural basis for specific inhibition of the deubiquitinase UCHL1

Ubiquitination regulates protein homeostasis and is tightly controlled by deubiquitinases (DUBs). Loss of the DUB UCHL1 leads to neurodegeneration, and its dysregulation promotes cancer metastasis and invasiveness. Small molecule probes for UCHL1 and DUBs in general could help investigate their func...

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Detalles Bibliográficos
Autores principales:	Grethe, Christian, Schmidt, Mirko, Kipka, Gian-Marvin, O’Dea, Rachel, Gallant, Kai, Janning, Petra, Gersch, Malte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549030/ https://www.ncbi.nlm.nih.gov/pubmed/36216817 http://dx.doi.org/10.1038/s41467-022-33559-4

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