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A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related study
BACKGROUND: A new disease entity called multisystem inflammatory syndrome in children (MIS-C) is a rare consequence of COVID-19 infection. The pathophysiology and risk factors of MIS-C are still unclear, and the clinical manifestation ranges from milder forms to cases needing intensive care unit tre...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549035/ https://www.ncbi.nlm.nih.gov/pubmed/36225207 http://dx.doi.org/10.3389/fendo.2022.934373 |
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author | Gawlik, Aneta Monika Berdej-Szczot, Elżbieta Chmiel, Iga Lorek, Miłosz Antosz, Aleksandra Firek-Pędras, Małgorzata Szydłowski, Lesław Ludwikowska, Kamila Maria Okarska-Napierała, Magdalena Dudek, Natalia Piwoński, Krzysztof Afelt, Aneta Suski-Grabowski, Catherine Kursa, Miron Bartosz Kuchar, Ernest Szenborn, Leszek Jackowska, Teresa Peregud-Pogorzelski, Jarosław Mazur, Artur |
author_facet | Gawlik, Aneta Monika Berdej-Szczot, Elżbieta Chmiel, Iga Lorek, Miłosz Antosz, Aleksandra Firek-Pędras, Małgorzata Szydłowski, Lesław Ludwikowska, Kamila Maria Okarska-Napierała, Magdalena Dudek, Natalia Piwoński, Krzysztof Afelt, Aneta Suski-Grabowski, Catherine Kursa, Miron Bartosz Kuchar, Ernest Szenborn, Leszek Jackowska, Teresa Peregud-Pogorzelski, Jarosław Mazur, Artur |
author_sort | Gawlik, Aneta Monika |
collection | PubMed |
description | BACKGROUND: A new disease entity called multisystem inflammatory syndrome in children (MIS-C) is a rare consequence of COVID-19 infection. The pathophysiology and risk factors of MIS-C are still unclear, and the clinical manifestation ranges from milder forms to cases needing intensive care unit treatment. Based on available data, obesity is linked to pro-inflammatory stimulation. Moreover, several studies showed that obesity could play a role in COVID-19 severity and its comorbidities among the adult and children’s populations. This study aimed to investigate the influence of overweightedness/obesity in childhood for the course of MIS-C in Poland. METHODS: This study presented data from the national MultiOrgan Inflammatory Syndromes COVID-19 Related Study (MOIS-CoR) collected between 4 March 2020 and 20 February 2021. Of the 371 patients that met the Polish MIS-C criteria, 306 were included for further analysis. RESULTS: Children who are obese (OB with body mass index (BMI) ≥95th percentile) and overweight (OV with BMI ≥85th percentile but <95th percentile) (28 and 49 patients, respectively) represented 25.1% (n=77) of all recruited patients. Complete recovery at the time of discharge presented in 93% of normal body weight (NW) participants and 90% of OV children (p>0.05). Among OB children, 76% recovered fully, which differed from the NW group (p=0.01). Calculated odds ratio (OR) of incomplete recovery for OB children was 4.2. Irrespective of body weight, there were no differences (p>0.05) in the length of hospitalization and the duration of symptoms (for OB, 13 and 16.5 days; for OV and NW, 10 and 14 days, respectively), as well as in the frequency of cardiovascular abnormalities, necessity of oxygen therapy (OB, 26.9%; OV, 23.9%; and NW, 20.7%), and intravenous immunoglobulin and glucocorticosteroid (GCS) treatment. CONCLUSION: The higher risk of incomplete recovery and observed tendency toward a worsening course of MIS-C in patients with obesity suggest the need for further studies to confirm and understand our findings. |
format | Online Article Text |
id | pubmed-9549035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95490352022-10-11 A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related study Gawlik, Aneta Monika Berdej-Szczot, Elżbieta Chmiel, Iga Lorek, Miłosz Antosz, Aleksandra Firek-Pędras, Małgorzata Szydłowski, Lesław Ludwikowska, Kamila Maria Okarska-Napierała, Magdalena Dudek, Natalia Piwoński, Krzysztof Afelt, Aneta Suski-Grabowski, Catherine Kursa, Miron Bartosz Kuchar, Ernest Szenborn, Leszek Jackowska, Teresa Peregud-Pogorzelski, Jarosław Mazur, Artur Front Endocrinol (Lausanne) Endocrinology BACKGROUND: A new disease entity called multisystem inflammatory syndrome in children (MIS-C) is a rare consequence of COVID-19 infection. The pathophysiology and risk factors of MIS-C are still unclear, and the clinical manifestation ranges from milder forms to cases needing intensive care unit treatment. Based on available data, obesity is linked to pro-inflammatory stimulation. Moreover, several studies showed that obesity could play a role in COVID-19 severity and its comorbidities among the adult and children’s populations. This study aimed to investigate the influence of overweightedness/obesity in childhood for the course of MIS-C in Poland. METHODS: This study presented data from the national MultiOrgan Inflammatory Syndromes COVID-19 Related Study (MOIS-CoR) collected between 4 March 2020 and 20 February 2021. Of the 371 patients that met the Polish MIS-C criteria, 306 were included for further analysis. RESULTS: Children who are obese (OB with body mass index (BMI) ≥95th percentile) and overweight (OV with BMI ≥85th percentile but <95th percentile) (28 and 49 patients, respectively) represented 25.1% (n=77) of all recruited patients. Complete recovery at the time of discharge presented in 93% of normal body weight (NW) participants and 90% of OV children (p>0.05). Among OB children, 76% recovered fully, which differed from the NW group (p=0.01). Calculated odds ratio (OR) of incomplete recovery for OB children was 4.2. Irrespective of body weight, there were no differences (p>0.05) in the length of hospitalization and the duration of symptoms (for OB, 13 and 16.5 days; for OV and NW, 10 and 14 days, respectively), as well as in the frequency of cardiovascular abnormalities, necessity of oxygen therapy (OB, 26.9%; OV, 23.9%; and NW, 20.7%), and intravenous immunoglobulin and glucocorticosteroid (GCS) treatment. CONCLUSION: The higher risk of incomplete recovery and observed tendency toward a worsening course of MIS-C in patients with obesity suggest the need for further studies to confirm and understand our findings. Frontiers Media S.A. 2022-09-26 /pmc/articles/PMC9549035/ /pubmed/36225207 http://dx.doi.org/10.3389/fendo.2022.934373 Text en Copyright © 2022 Gawlik, Berdej-Szczot, Chmiel, Lorek, Antosz, Firek-Pędras, Szydłowski, Ludwikowska, Okarska-Napierała, Dudek, Piwoński, Afelt, Suski-Grabowski, Kursa, Kuchar, Szenborn, Jackowska, Peregud-Pogorzelski and Mazur https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Gawlik, Aneta Monika Berdej-Szczot, Elżbieta Chmiel, Iga Lorek, Miłosz Antosz, Aleksandra Firek-Pędras, Małgorzata Szydłowski, Lesław Ludwikowska, Kamila Maria Okarska-Napierała, Magdalena Dudek, Natalia Piwoński, Krzysztof Afelt, Aneta Suski-Grabowski, Catherine Kursa, Miron Bartosz Kuchar, Ernest Szenborn, Leszek Jackowska, Teresa Peregud-Pogorzelski, Jarosław Mazur, Artur A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related study |
title | A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related study |
title_full | A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related study |
title_fullStr | A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related study |
title_full_unstemmed | A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related study |
title_short | A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related study |
title_sort | tendency to worse course of multisystem inflammatory syndrome in children with obesity: multiorgan inflammatory syndromes covid-19 related study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549035/ https://www.ncbi.nlm.nih.gov/pubmed/36225207 http://dx.doi.org/10.3389/fendo.2022.934373 |
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