Pharmacokinetic Evidence of Steady and Sustained Drug Release from Long-Acting Implantable Corticosteroid Matrices for Chronic Rhinosinusitis

BACKGROUND: The efficacy of topical corticosteroids is limited in chronic rhinosinusitis (CRS) due to rapid clearance from the nasal cavity and insufficient drug delivery to inflamed sinonasal passages. LYR-210 is an implantable corticosteroid matrix designed to provide up to 24 weeks of treatment t...

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Detalles Bibliográficos
Autores principales: Ow, Randall A., Shotts, Steven, Kakarlapudi, Venkata, McIntyre, John, Naclerio, Robert M., You, Changcheng, Pappas, Alexander, Brayton, Lindsay, Kuang, Yina, Shao, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549255/
https://www.ncbi.nlm.nih.gov/pubmed/35708181
http://dx.doi.org/10.1177/19458924221107200

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