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Polypharmacology-based approach for screening TCM against coinfection of Mycoplasma gallisepticum and Escherichia coli

Natural products and their unique polypharmacology offer significant advantages for finding novel therapeutics particularly for the treatment of complex diseases. Meanwhile, Traditional Chinese Medicine exerts overall clinical benefits through a multi-component and multi-target approach. In this stu...

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Autores principales: Bao, Jiaxin, Wang, Yuan, Wang, Shun, Niu, Dong, Wang, Ze, Li, Rui, Zheng, Yadan, Ishfaq, Muhammad, Wu, Zhiyong, Li, Jichang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549337/
https://www.ncbi.nlm.nih.gov/pubmed/36225794
http://dx.doi.org/10.3389/fvets.2022.972245
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author Bao, Jiaxin
Wang, Yuan
Wang, Shun
Niu, Dong
Wang, Ze
Li, Rui
Zheng, Yadan
Ishfaq, Muhammad
Wu, Zhiyong
Li, Jichang
author_facet Bao, Jiaxin
Wang, Yuan
Wang, Shun
Niu, Dong
Wang, Ze
Li, Rui
Zheng, Yadan
Ishfaq, Muhammad
Wu, Zhiyong
Li, Jichang
author_sort Bao, Jiaxin
collection PubMed
description Natural products and their unique polypharmacology offer significant advantages for finding novel therapeutics particularly for the treatment of complex diseases. Meanwhile, Traditional Chinese Medicine exerts overall clinical benefits through a multi-component and multi-target approach. In this study, we used the previously established co-infection model of Mycoplasma gallisepticum and Escherichia coli as a representative of complex diseases. A new combination consisting of 6 herbs were obtained by using network pharmacology combined with transcriptomic analysis to reverse screen TCMs from the Chinese medicine database, containing Isatdis Radix, Forsythia Fructus, Ginkgo Folium, Mori Cortex, Licorice, and Radix Salviae. The results of therapeutic trials showed that the Chinese herbal compounds screened by the target network played a good therapeutic effect in the case of co-infection. In summary, these data suggested a new method to validate target combinations of natural products that can be used to optimize their multiple structure-activity relationships to obtain drug-like natural product derivatives.
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spelling pubmed-95493372022-10-11 Polypharmacology-based approach for screening TCM against coinfection of Mycoplasma gallisepticum and Escherichia coli Bao, Jiaxin Wang, Yuan Wang, Shun Niu, Dong Wang, Ze Li, Rui Zheng, Yadan Ishfaq, Muhammad Wu, Zhiyong Li, Jichang Front Vet Sci Veterinary Science Natural products and their unique polypharmacology offer significant advantages for finding novel therapeutics particularly for the treatment of complex diseases. Meanwhile, Traditional Chinese Medicine exerts overall clinical benefits through a multi-component and multi-target approach. In this study, we used the previously established co-infection model of Mycoplasma gallisepticum and Escherichia coli as a representative of complex diseases. A new combination consisting of 6 herbs were obtained by using network pharmacology combined with transcriptomic analysis to reverse screen TCMs from the Chinese medicine database, containing Isatdis Radix, Forsythia Fructus, Ginkgo Folium, Mori Cortex, Licorice, and Radix Salviae. The results of therapeutic trials showed that the Chinese herbal compounds screened by the target network played a good therapeutic effect in the case of co-infection. In summary, these data suggested a new method to validate target combinations of natural products that can be used to optimize their multiple structure-activity relationships to obtain drug-like natural product derivatives. Frontiers Media S.A. 2022-09-26 /pmc/articles/PMC9549337/ /pubmed/36225794 http://dx.doi.org/10.3389/fvets.2022.972245 Text en Copyright © 2022 Bao, Wang, Wang, Niu, Wang, Li, Zheng, Ishfaq, Wu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Bao, Jiaxin
Wang, Yuan
Wang, Shun
Niu, Dong
Wang, Ze
Li, Rui
Zheng, Yadan
Ishfaq, Muhammad
Wu, Zhiyong
Li, Jichang
Polypharmacology-based approach for screening TCM against coinfection of Mycoplasma gallisepticum and Escherichia coli
title Polypharmacology-based approach for screening TCM against coinfection of Mycoplasma gallisepticum and Escherichia coli
title_full Polypharmacology-based approach for screening TCM against coinfection of Mycoplasma gallisepticum and Escherichia coli
title_fullStr Polypharmacology-based approach for screening TCM against coinfection of Mycoplasma gallisepticum and Escherichia coli
title_full_unstemmed Polypharmacology-based approach for screening TCM against coinfection of Mycoplasma gallisepticum and Escherichia coli
title_short Polypharmacology-based approach for screening TCM against coinfection of Mycoplasma gallisepticum and Escherichia coli
title_sort polypharmacology-based approach for screening tcm against coinfection of mycoplasma gallisepticum and escherichia coli
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549337/
https://www.ncbi.nlm.nih.gov/pubmed/36225794
http://dx.doi.org/10.3389/fvets.2022.972245
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