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Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease

ABSTRACT: Immunoperinatology is an emerging field. Transdisciplinary efforts by physicians, physician‐scientists, basic science researchers, and computational biologists have made substantial advancements by identifying unique immunologic signatures of specific diseases, discovering innovative preve...

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Autores principales: Ozen, Maide, Aghaeepour, Nima, Marić, Ivana, Wong, Ronald J., Stevenson, David K., Jantzie, Lauren L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549444/
https://www.ncbi.nlm.nih.gov/pubmed/36216868
http://dx.doi.org/10.1038/s41390-022-02335-x
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author Ozen, Maide
Aghaeepour, Nima
Marić, Ivana
Wong, Ronald J.
Stevenson, David K.
Jantzie, Lauren L.
author_facet Ozen, Maide
Aghaeepour, Nima
Marić, Ivana
Wong, Ronald J.
Stevenson, David K.
Jantzie, Lauren L.
author_sort Ozen, Maide
collection PubMed
description ABSTRACT: Immunoperinatology is an emerging field. Transdisciplinary efforts by physicians, physician‐scientists, basic science researchers, and computational biologists have made substantial advancements by identifying unique immunologic signatures of specific diseases, discovering innovative preventative or treatment strategies, and establishing foundations for individualized neonatal intensive care of the most vulnerable neonates. In this review, we summarize the immunobiology and immunopathology of pregnancy, highlight omics approaches to study the maternal–fetal interface, and their contributions to pregnancy health. We examined the importance of transdisciplinary, multiomic (such as genomics, transcriptomics, proteomics, metabolomics, and immunomics) and machine-learning strategies in unraveling the mechanisms of adverse pregnancy, neonatal, and childhood outcomes and how they can guide the development of novel therapies to improve maternal and neonatal health. IMPACT: Discuss immunoperinatology research from the lens of omics and machine-learning approaches. Identify opportunities for omics-based approaches to delineate infection/inflammation-associated maternal, neonatal, and later life adverse outcomes (e.g., histologic chorioamnionitis [HCA]).
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spelling pubmed-95494442022-10-11 Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease Ozen, Maide Aghaeepour, Nima Marić, Ivana Wong, Ronald J. Stevenson, David K. Jantzie, Lauren L. Pediatr Res Review Article ABSTRACT: Immunoperinatology is an emerging field. Transdisciplinary efforts by physicians, physician‐scientists, basic science researchers, and computational biologists have made substantial advancements by identifying unique immunologic signatures of specific diseases, discovering innovative preventative or treatment strategies, and establishing foundations for individualized neonatal intensive care of the most vulnerable neonates. In this review, we summarize the immunobiology and immunopathology of pregnancy, highlight omics approaches to study the maternal–fetal interface, and their contributions to pregnancy health. We examined the importance of transdisciplinary, multiomic (such as genomics, transcriptomics, proteomics, metabolomics, and immunomics) and machine-learning strategies in unraveling the mechanisms of adverse pregnancy, neonatal, and childhood outcomes and how they can guide the development of novel therapies to improve maternal and neonatal health. IMPACT: Discuss immunoperinatology research from the lens of omics and machine-learning approaches. Identify opportunities for omics-based approaches to delineate infection/inflammation-associated maternal, neonatal, and later life adverse outcomes (e.g., histologic chorioamnionitis [HCA]). Nature Publishing Group US 2022-10-10 2023 /pmc/articles/PMC9549444/ /pubmed/36216868 http://dx.doi.org/10.1038/s41390-022-02335-x Text en © The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Ozen, Maide
Aghaeepour, Nima
Marić, Ivana
Wong, Ronald J.
Stevenson, David K.
Jantzie, Lauren L.
Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease
title Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease
title_full Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease
title_fullStr Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease
title_full_unstemmed Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease
title_short Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease
title_sort omics approaches: interactions at the maternal–fetal interface and origins of child health and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549444/
https://www.ncbi.nlm.nih.gov/pubmed/36216868
http://dx.doi.org/10.1038/s41390-022-02335-x
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