Inhibition of TRPC4 channel activity in colonic myocytes by tricyclic antidepressants disrupts colonic motility causing constipation

Tricyclic antidepressants (TCAs) have been used to treat depression and were recently approved for treating irritable bowel syndrome (IBS) patients with severe or refractory IBS symptoms. However, the molecular mechanism of TCA action in the gastrointestinal (GI) tract remains poorly understood. Tra...

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Detalles Bibliográficos
Autores principales: Jeong, Byeongseok, Sung, Tae Sik, Jeon, Dongju, Park, Kyu Joo, Jun, Jae Yeoul, So, Insuk, Hong, Chansik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549500/
https://www.ncbi.nlm.nih.gov/pubmed/35560982
http://dx.doi.org/10.1111/jcmm.17348

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