Cargando…

Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in α‐synuclein transgenic mice

Olfactory impairment is an initial non‐motor symptom of Parkinson's disease that causes the deposition of aggregated α‐synuclein (α‐syn) in olfactory neurons. Transient receptor potential canonical (TRPC) channels are a diverse group of non‐selective Ca(2+) entry channels involved in the progre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Min, Liu, Jia, Luo, Hanjiang, Duan, Chunli, Gao, Ge, Yang, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549507/ https://www.ncbi.nlm.nih.gov/pubmed/36029194 http://dx.doi.org/10.1111/jcmm.17524

Ejemplares similares

Olfactory Dysfunction and Neurotransmitter Disturbance in Olfactory Bulb of Transgenic Mice Expressing Human A53T Mutant α-Synuclein
por: Zhang, Sufang, et al.
Publicado: (2015)

Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy
por: Liu, Jia, et al.
Publicado: (2017)

Network dysfunction in α‐synuclein transgenic mice and human Lewy body dementia
por: Morris, Meaghan, et al.
Publicado: (2015)

Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra
por: McCormack, A L, et al.
Publicado: (2012)

Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice
por: Naudet, Nicolas, et al.
Publicado: (2017)

The Temporal Expression Pattern of Alpha-Synuclein Modulates Olfactory Neurogenesis in Transgenic Mice
por: Schreglmann, Sebastian R., et al.
Publicado: (2015)

Aerobic Exercise Improves Methamphetamine-Induced Olfactory Dysfunction Through α-Synuclein Intervention in Male Mice
por: Wang, Zhuo, et al.
Publicado: (2022)

Progression of phosphorylated α‐synuclein in Macaca fuscata
por: Kawakami, Ito, et al.
Publicado: (2021)

Contribution of Alanine-76 and Serine Phosphorylation in α-Synuclein Membrane Association and Aggregation in Yeasts
por: Fiske, Michael, et al.
Publicado: (2011)

Ambroxol effects in glucocerebrosidase and α‐synuclein transgenic mice
por: Migdalska‐Richards, Anna, et al.
Publicado: (2016)

Pramipexole Reduces Phosphorylation of α-Synuclein at Serine-129
por: Chau, Kai-Yin, et al.
Publicado: (2013)

The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
por: Kawakami, Fumitaka, et al.
Publicado: (2015)

α-Synuclein serine129 phosphorylation – the physiology of pathology
por: Ramalingam, Nagendran, et al.
Publicado: (2023)

Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation
por: Reimer, Lasse, et al.
Publicado: (2022)

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies
por: Kawahata, Ichiro, et al.
Publicado: (2022)

Mutants in Drosophila TRPC Channels Reduce Olfactory Sensitivity to Carbon Dioxide
por: Badsha, Farhath, et al.
Publicado: (2012)

Effects of α-Synuclein Overexpression in Transgenic Caenorhabditis elegans Strains
por: Bodhicharla, Rakesh, et al.
Publicado: (2012)

α-synuclein inclusions are abundant in non-neuronal cells in the anterior olfactory nucleus of the Parkinson’s disease olfactory bulb
por: Stevenson, Taylor J., et al.
Publicado: (2020)

Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease
por: Kallhoff, Verena, et al.
Publicado: (2007)

Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis
por: Lloyd, Grace M., et al.
Publicado: (2023)

The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
por: Sexton, Jane E., et al.
Publicado: (2016)

The Serine 814 of TRPC6 Is Phosphorylated under Unstimulated Conditions
por: Bousquet, Simon M., et al.
Publicado: (2011)

Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice
por: Spinelli, Kateri J., et al.
Publicado: (2015)

Alpha-Synuclein Function and Dysfunction on Cellular Membranes
por: Snead, David, et al.
Publicado: (2014)

Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease
por: Yan, Yaping, et al.
Publicado: (2021)

Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse
por: Oien, Derek B., et al.
Publicado: (2011)

α-Synuclein aggregation in the olfactory bulb induces olfactory deficits by perturbing granule cells and granular–mitral synaptic transmission
por: Chen, Fengjiao, et al.
Publicado: (2021)

Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
por: Spencer, Brian, et al.
Publicado: (2017)

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils
por: Dhillon, Jess-Karan S., et al.
Publicado: (2019)

Membrane Binding of Parkinson's Protein α‐Synuclein: Effect of Phosphorylation at Positions 87 and 129 by the S to D Mutation Approach
por: Kumar, Pravin, et al.
Publicado: (2016)

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation
por: Scheibe, Christian, et al.
Publicado: (2021)

Cooperativity of α-Synuclein Binding to Lipid Membranes
por: Makasewicz, Katarzyna, et al.
Publicado: (2021)

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice
por: Rey, Nolwen L., et al.
Publicado: (2013)

Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease
por: Bongianni, Matilde, et al.
Publicado: (2022)

Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity
por: Stewart, Tessandra, et al.
Publicado: (2015)

Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson's Disease
por: Castillo-Gonzalez, Juan Antonio, et al.
Publicado: (2017)

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates
por: Arawaka, Shigeki, et al.
Publicado: (2017)

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy
por: Dai, Lijun, et al.
Publicado: (2021)

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity
por: Ramalingam, Nagendran, et al.
Publicado: (2023)

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
por: Ysselstein, Daniel, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_op7en2u1tjjmahgrtfso2n3rge