TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

In some types of cancer, telomere length is maintained by the alternative lengthening of telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation syndrome X‐linked (ATRX) gene is mutated leading to the conclusion that the ATRX complex represses ALT. Here, we report that m...

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Detalles Bibliográficos
Autores principales: de Nonneville, Alexandre, Salas, Sébastien, Bertucci, François, Sobinoff, Alexander P, Adélaïde, José, Guille, Arnaud, Finetti, Pascal, Noble, Jane R, Churikov, Dimitri, Chaffanet, Max, Lavit, Elise, Pickett, Hilda A, Bouvier, Corinne, Birnbaum, Daniel, Reddel, Roger R, Géli, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549729/
https://www.ncbi.nlm.nih.gov/pubmed/35920001
http://dx.doi.org/10.15252/emmm.202215859

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