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In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO

Morphological changes that may arise through a treatment course are probably one of the most significant sources of range uncertainty in proton therapy. Non-invasive in-vivo treatment monitoring is useful to increase treatment quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner pe...

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Autores principales: Moglioni, Martina, Kraan, Aafke Christine, Baroni, Guido, Battistoni, Giuseppe, Belcari, Nicola, Berti, Andrea, Carra, Pietro, Cerello, Piergiorgio, Ciocca, Mario, De Gregorio, Angelica, De Simoni, Micol, Del Sarto, Damiano, Donetti, Marco, Dong, Yunsheng, Embriaco, Alessia, Fantacci, Maria Evelina, Ferrero, Veronica, Fiorina, Elisa, Fischetti, Marta, Franciosini, Gaia, Giraudo, Giuseppe, Laruina, Francesco, Maestri, Davide, Magi, Marco, Magro, Giuseppe, Malekzadeh, Etesam, Marafini, Michela, Mattei, Ilaria, Mazzoni, Enrico, Mereu, Paolo, Mirandola, Alfredo, Morrocchi, Matteo, Muraro, Silvia, Orlandi, Ester, Patera, Vincenzo, Pennazio, Francesco, Pullia, Marco, Retico, Alessandra, Rivetti, Angelo, Da Rocha Rolo, Manuel Dionisio, Rosso, Valeria, Sarti, Alessio, Schiavi, Angelo, Sciubba, Adalberto, Sportelli, Giancarlo, Tampellini, Sara, Toppi, Marco, Traini, Giacomo, Trigilio, Antonio, Valle, Serena Marta, Valvo, Francesca, Vischioni, Barbara, Vitolo, Viviana, Wheadon, Richard, Bisogni, Maria Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549776/
https://www.ncbi.nlm.nih.gov/pubmed/36226070
http://dx.doi.org/10.3389/fonc.2022.929949
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author Moglioni, Martina
Kraan, Aafke Christine
Baroni, Guido
Battistoni, Giuseppe
Belcari, Nicola
Berti, Andrea
Carra, Pietro
Cerello, Piergiorgio
Ciocca, Mario
De Gregorio, Angelica
De Simoni, Micol
Del Sarto, Damiano
Donetti, Marco
Dong, Yunsheng
Embriaco, Alessia
Fantacci, Maria Evelina
Ferrero, Veronica
Fiorina, Elisa
Fischetti, Marta
Franciosini, Gaia
Giraudo, Giuseppe
Laruina, Francesco
Maestri, Davide
Magi, Marco
Magro, Giuseppe
Malekzadeh, Etesam
Marafini, Michela
Mattei, Ilaria
Mazzoni, Enrico
Mereu, Paolo
Mirandola, Alfredo
Morrocchi, Matteo
Muraro, Silvia
Orlandi, Ester
Patera, Vincenzo
Pennazio, Francesco
Pullia, Marco
Retico, Alessandra
Rivetti, Angelo
Da Rocha Rolo, Manuel Dionisio
Rosso, Valeria
Sarti, Alessio
Schiavi, Angelo
Sciubba, Adalberto
Sportelli, Giancarlo
Tampellini, Sara
Toppi, Marco
Traini, Giacomo
Trigilio, Antonio
Valle, Serena Marta
Valvo, Francesca
Vischioni, Barbara
Vitolo, Viviana
Wheadon, Richard
Bisogni, Maria Giuseppina
author_facet Moglioni, Martina
Kraan, Aafke Christine
Baroni, Guido
Battistoni, Giuseppe
Belcari, Nicola
Berti, Andrea
Carra, Pietro
Cerello, Piergiorgio
Ciocca, Mario
De Gregorio, Angelica
De Simoni, Micol
Del Sarto, Damiano
Donetti, Marco
Dong, Yunsheng
Embriaco, Alessia
Fantacci, Maria Evelina
Ferrero, Veronica
Fiorina, Elisa
Fischetti, Marta
Franciosini, Gaia
Giraudo, Giuseppe
Laruina, Francesco
Maestri, Davide
Magi, Marco
Magro, Giuseppe
Malekzadeh, Etesam
Marafini, Michela
Mattei, Ilaria
Mazzoni, Enrico
Mereu, Paolo
Mirandola, Alfredo
Morrocchi, Matteo
Muraro, Silvia
Orlandi, Ester
Patera, Vincenzo
Pennazio, Francesco
Pullia, Marco
Retico, Alessandra
Rivetti, Angelo
Da Rocha Rolo, Manuel Dionisio
Rosso, Valeria
Sarti, Alessio
Schiavi, Angelo
Sciubba, Adalberto
Sportelli, Giancarlo
Tampellini, Sara
Toppi, Marco
Traini, Giacomo
Trigilio, Antonio
Valle, Serena Marta
Valvo, Francesca
Vischioni, Barbara
Vitolo, Viviana
Wheadon, Richard
Bisogni, Maria Giuseppina
author_sort Moglioni, Martina
collection PubMed
description Morphological changes that may arise through a treatment course are probably one of the most significant sources of range uncertainty in proton therapy. Non-invasive in-vivo treatment monitoring is useful to increase treatment quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs in-vivo range monitoring in proton and carbon therapy treatments at the National Center of Oncological Hadrontherapy (CNAO). It is currently in a clinical trial (ID: NCT03662373) and has acquired in-beam PET data during the treatment of various patients. In this work we analyze the in-beam PET (IB-PET) data of eight patients treated with proton therapy at CNAO. The goal of the analysis is twofold. First, we assess the level of experimental fluctuations in inter-fractional range differences (sensitivity) of the INSIDE PET system by studying patients without morphological changes. Second, we use the obtained results to see whether we can observe anomalously large range variations in patients where morphological changes have occurred. The sensitivity of the INSIDE IB-PET scanner was quantified as the standard deviation of the range difference distributions observed for six patients that did not show morphological changes. Inter-fractional range variations with respect to a reference distribution were estimated using the Most-Likely-Shift (MLS) method. To establish the efficacy of this method, we made a comparison with the Beam’s Eye View (BEV) method. For patients showing no morphological changes in the control CT the average range variation standard deviation was found to be 2.5 mm with the MLS method and 2.3 mm with the BEV method. On the other hand, for patients where some small anatomical changes occurred, we found larger standard deviation values. In these patients we evaluated where anomalous range differences were found and compared them with the CT. We found that the identified regions were mostly in agreement with the morphological changes seen in the CT scan.
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spelling pubmed-95497762022-10-11 In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO Moglioni, Martina Kraan, Aafke Christine Baroni, Guido Battistoni, Giuseppe Belcari, Nicola Berti, Andrea Carra, Pietro Cerello, Piergiorgio Ciocca, Mario De Gregorio, Angelica De Simoni, Micol Del Sarto, Damiano Donetti, Marco Dong, Yunsheng Embriaco, Alessia Fantacci, Maria Evelina Ferrero, Veronica Fiorina, Elisa Fischetti, Marta Franciosini, Gaia Giraudo, Giuseppe Laruina, Francesco Maestri, Davide Magi, Marco Magro, Giuseppe Malekzadeh, Etesam Marafini, Michela Mattei, Ilaria Mazzoni, Enrico Mereu, Paolo Mirandola, Alfredo Morrocchi, Matteo Muraro, Silvia Orlandi, Ester Patera, Vincenzo Pennazio, Francesco Pullia, Marco Retico, Alessandra Rivetti, Angelo Da Rocha Rolo, Manuel Dionisio Rosso, Valeria Sarti, Alessio Schiavi, Angelo Sciubba, Adalberto Sportelli, Giancarlo Tampellini, Sara Toppi, Marco Traini, Giacomo Trigilio, Antonio Valle, Serena Marta Valvo, Francesca Vischioni, Barbara Vitolo, Viviana Wheadon, Richard Bisogni, Maria Giuseppina Front Oncol Oncology Morphological changes that may arise through a treatment course are probably one of the most significant sources of range uncertainty in proton therapy. Non-invasive in-vivo treatment monitoring is useful to increase treatment quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs in-vivo range monitoring in proton and carbon therapy treatments at the National Center of Oncological Hadrontherapy (CNAO). It is currently in a clinical trial (ID: NCT03662373) and has acquired in-beam PET data during the treatment of various patients. In this work we analyze the in-beam PET (IB-PET) data of eight patients treated with proton therapy at CNAO. The goal of the analysis is twofold. First, we assess the level of experimental fluctuations in inter-fractional range differences (sensitivity) of the INSIDE PET system by studying patients without morphological changes. Second, we use the obtained results to see whether we can observe anomalously large range variations in patients where morphological changes have occurred. The sensitivity of the INSIDE IB-PET scanner was quantified as the standard deviation of the range difference distributions observed for six patients that did not show morphological changes. Inter-fractional range variations with respect to a reference distribution were estimated using the Most-Likely-Shift (MLS) method. To establish the efficacy of this method, we made a comparison with the Beam’s Eye View (BEV) method. For patients showing no morphological changes in the control CT the average range variation standard deviation was found to be 2.5 mm with the MLS method and 2.3 mm with the BEV method. On the other hand, for patients where some small anatomical changes occurred, we found larger standard deviation values. In these patients we evaluated where anomalous range differences were found and compared them with the CT. We found that the identified regions were mostly in agreement with the morphological changes seen in the CT scan. Frontiers Media S.A. 2022-09-26 /pmc/articles/PMC9549776/ /pubmed/36226070 http://dx.doi.org/10.3389/fonc.2022.929949 Text en Copyright © 2022 Moglioni, Kraan, Baroni, Battistoni, Belcari, Berti, Carra, Cerello, Ciocca, De Gregorio, De Simoni, Del Sarto, Donetti, Dong, Embriaco, Fantacci, Ferrero, Fiorina, Fischetti, Franciosini, Giraudo, Laruina, Maestri, Magi, Magro, Malekzadeh, Marafini, Mattei, Mazzoni, Mereu, Mirandola, Morrocchi, Muraro, Orlandi, Patera, Pennazio, Pullia, Retico, Rivetti, Da Rocha Rolo, Rosso, Sarti, Schiavi, Sciubba, Sportelli, Tampellini, Toppi, Traini, Trigilio, Valle, Valvo, Vischioni, Vitolo, Wheadon and Bisogni https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Moglioni, Martina
Kraan, Aafke Christine
Baroni, Guido
Battistoni, Giuseppe
Belcari, Nicola
Berti, Andrea
Carra, Pietro
Cerello, Piergiorgio
Ciocca, Mario
De Gregorio, Angelica
De Simoni, Micol
Del Sarto, Damiano
Donetti, Marco
Dong, Yunsheng
Embriaco, Alessia
Fantacci, Maria Evelina
Ferrero, Veronica
Fiorina, Elisa
Fischetti, Marta
Franciosini, Gaia
Giraudo, Giuseppe
Laruina, Francesco
Maestri, Davide
Magi, Marco
Magro, Giuseppe
Malekzadeh, Etesam
Marafini, Michela
Mattei, Ilaria
Mazzoni, Enrico
Mereu, Paolo
Mirandola, Alfredo
Morrocchi, Matteo
Muraro, Silvia
Orlandi, Ester
Patera, Vincenzo
Pennazio, Francesco
Pullia, Marco
Retico, Alessandra
Rivetti, Angelo
Da Rocha Rolo, Manuel Dionisio
Rosso, Valeria
Sarti, Alessio
Schiavi, Angelo
Sciubba, Adalberto
Sportelli, Giancarlo
Tampellini, Sara
Toppi, Marco
Traini, Giacomo
Trigilio, Antonio
Valle, Serena Marta
Valvo, Francesca
Vischioni, Barbara
Vitolo, Viviana
Wheadon, Richard
Bisogni, Maria Giuseppina
In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO
title In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO
title_full In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO
title_fullStr In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO
title_full_unstemmed In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO
title_short In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO
title_sort in-vivo range verification analysis with in-beam pet data for patients treated with proton therapy at cnao
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549776/
https://www.ncbi.nlm.nih.gov/pubmed/36226070
http://dx.doi.org/10.3389/fonc.2022.929949
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