Cargando…
In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO
Morphological changes that may arise through a treatment course are probably one of the most significant sources of range uncertainty in proton therapy. Non-invasive in-vivo treatment monitoring is useful to increase treatment quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner pe...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549776/ https://www.ncbi.nlm.nih.gov/pubmed/36226070 http://dx.doi.org/10.3389/fonc.2022.929949 |
_version_ | 1784805745718460416 |
---|---|
author | Moglioni, Martina Kraan, Aafke Christine Baroni, Guido Battistoni, Giuseppe Belcari, Nicola Berti, Andrea Carra, Pietro Cerello, Piergiorgio Ciocca, Mario De Gregorio, Angelica De Simoni, Micol Del Sarto, Damiano Donetti, Marco Dong, Yunsheng Embriaco, Alessia Fantacci, Maria Evelina Ferrero, Veronica Fiorina, Elisa Fischetti, Marta Franciosini, Gaia Giraudo, Giuseppe Laruina, Francesco Maestri, Davide Magi, Marco Magro, Giuseppe Malekzadeh, Etesam Marafini, Michela Mattei, Ilaria Mazzoni, Enrico Mereu, Paolo Mirandola, Alfredo Morrocchi, Matteo Muraro, Silvia Orlandi, Ester Patera, Vincenzo Pennazio, Francesco Pullia, Marco Retico, Alessandra Rivetti, Angelo Da Rocha Rolo, Manuel Dionisio Rosso, Valeria Sarti, Alessio Schiavi, Angelo Sciubba, Adalberto Sportelli, Giancarlo Tampellini, Sara Toppi, Marco Traini, Giacomo Trigilio, Antonio Valle, Serena Marta Valvo, Francesca Vischioni, Barbara Vitolo, Viviana Wheadon, Richard Bisogni, Maria Giuseppina |
author_facet | Moglioni, Martina Kraan, Aafke Christine Baroni, Guido Battistoni, Giuseppe Belcari, Nicola Berti, Andrea Carra, Pietro Cerello, Piergiorgio Ciocca, Mario De Gregorio, Angelica De Simoni, Micol Del Sarto, Damiano Donetti, Marco Dong, Yunsheng Embriaco, Alessia Fantacci, Maria Evelina Ferrero, Veronica Fiorina, Elisa Fischetti, Marta Franciosini, Gaia Giraudo, Giuseppe Laruina, Francesco Maestri, Davide Magi, Marco Magro, Giuseppe Malekzadeh, Etesam Marafini, Michela Mattei, Ilaria Mazzoni, Enrico Mereu, Paolo Mirandola, Alfredo Morrocchi, Matteo Muraro, Silvia Orlandi, Ester Patera, Vincenzo Pennazio, Francesco Pullia, Marco Retico, Alessandra Rivetti, Angelo Da Rocha Rolo, Manuel Dionisio Rosso, Valeria Sarti, Alessio Schiavi, Angelo Sciubba, Adalberto Sportelli, Giancarlo Tampellini, Sara Toppi, Marco Traini, Giacomo Trigilio, Antonio Valle, Serena Marta Valvo, Francesca Vischioni, Barbara Vitolo, Viviana Wheadon, Richard Bisogni, Maria Giuseppina |
author_sort | Moglioni, Martina |
collection | PubMed |
description | Morphological changes that may arise through a treatment course are probably one of the most significant sources of range uncertainty in proton therapy. Non-invasive in-vivo treatment monitoring is useful to increase treatment quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs in-vivo range monitoring in proton and carbon therapy treatments at the National Center of Oncological Hadrontherapy (CNAO). It is currently in a clinical trial (ID: NCT03662373) and has acquired in-beam PET data during the treatment of various patients. In this work we analyze the in-beam PET (IB-PET) data of eight patients treated with proton therapy at CNAO. The goal of the analysis is twofold. First, we assess the level of experimental fluctuations in inter-fractional range differences (sensitivity) of the INSIDE PET system by studying patients without morphological changes. Second, we use the obtained results to see whether we can observe anomalously large range variations in patients where morphological changes have occurred. The sensitivity of the INSIDE IB-PET scanner was quantified as the standard deviation of the range difference distributions observed for six patients that did not show morphological changes. Inter-fractional range variations with respect to a reference distribution were estimated using the Most-Likely-Shift (MLS) method. To establish the efficacy of this method, we made a comparison with the Beam’s Eye View (BEV) method. For patients showing no morphological changes in the control CT the average range variation standard deviation was found to be 2.5 mm with the MLS method and 2.3 mm with the BEV method. On the other hand, for patients where some small anatomical changes occurred, we found larger standard deviation values. In these patients we evaluated where anomalous range differences were found and compared them with the CT. We found that the identified regions were mostly in agreement with the morphological changes seen in the CT scan. |
format | Online Article Text |
id | pubmed-9549776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95497762022-10-11 In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO Moglioni, Martina Kraan, Aafke Christine Baroni, Guido Battistoni, Giuseppe Belcari, Nicola Berti, Andrea Carra, Pietro Cerello, Piergiorgio Ciocca, Mario De Gregorio, Angelica De Simoni, Micol Del Sarto, Damiano Donetti, Marco Dong, Yunsheng Embriaco, Alessia Fantacci, Maria Evelina Ferrero, Veronica Fiorina, Elisa Fischetti, Marta Franciosini, Gaia Giraudo, Giuseppe Laruina, Francesco Maestri, Davide Magi, Marco Magro, Giuseppe Malekzadeh, Etesam Marafini, Michela Mattei, Ilaria Mazzoni, Enrico Mereu, Paolo Mirandola, Alfredo Morrocchi, Matteo Muraro, Silvia Orlandi, Ester Patera, Vincenzo Pennazio, Francesco Pullia, Marco Retico, Alessandra Rivetti, Angelo Da Rocha Rolo, Manuel Dionisio Rosso, Valeria Sarti, Alessio Schiavi, Angelo Sciubba, Adalberto Sportelli, Giancarlo Tampellini, Sara Toppi, Marco Traini, Giacomo Trigilio, Antonio Valle, Serena Marta Valvo, Francesca Vischioni, Barbara Vitolo, Viviana Wheadon, Richard Bisogni, Maria Giuseppina Front Oncol Oncology Morphological changes that may arise through a treatment course are probably one of the most significant sources of range uncertainty in proton therapy. Non-invasive in-vivo treatment monitoring is useful to increase treatment quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs in-vivo range monitoring in proton and carbon therapy treatments at the National Center of Oncological Hadrontherapy (CNAO). It is currently in a clinical trial (ID: NCT03662373) and has acquired in-beam PET data during the treatment of various patients. In this work we analyze the in-beam PET (IB-PET) data of eight patients treated with proton therapy at CNAO. The goal of the analysis is twofold. First, we assess the level of experimental fluctuations in inter-fractional range differences (sensitivity) of the INSIDE PET system by studying patients without morphological changes. Second, we use the obtained results to see whether we can observe anomalously large range variations in patients where morphological changes have occurred. The sensitivity of the INSIDE IB-PET scanner was quantified as the standard deviation of the range difference distributions observed for six patients that did not show morphological changes. Inter-fractional range variations with respect to a reference distribution were estimated using the Most-Likely-Shift (MLS) method. To establish the efficacy of this method, we made a comparison with the Beam’s Eye View (BEV) method. For patients showing no morphological changes in the control CT the average range variation standard deviation was found to be 2.5 mm with the MLS method and 2.3 mm with the BEV method. On the other hand, for patients where some small anatomical changes occurred, we found larger standard deviation values. In these patients we evaluated where anomalous range differences were found and compared them with the CT. We found that the identified regions were mostly in agreement with the morphological changes seen in the CT scan. Frontiers Media S.A. 2022-09-26 /pmc/articles/PMC9549776/ /pubmed/36226070 http://dx.doi.org/10.3389/fonc.2022.929949 Text en Copyright © 2022 Moglioni, Kraan, Baroni, Battistoni, Belcari, Berti, Carra, Cerello, Ciocca, De Gregorio, De Simoni, Del Sarto, Donetti, Dong, Embriaco, Fantacci, Ferrero, Fiorina, Fischetti, Franciosini, Giraudo, Laruina, Maestri, Magi, Magro, Malekzadeh, Marafini, Mattei, Mazzoni, Mereu, Mirandola, Morrocchi, Muraro, Orlandi, Patera, Pennazio, Pullia, Retico, Rivetti, Da Rocha Rolo, Rosso, Sarti, Schiavi, Sciubba, Sportelli, Tampellini, Toppi, Traini, Trigilio, Valle, Valvo, Vischioni, Vitolo, Wheadon and Bisogni https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Moglioni, Martina Kraan, Aafke Christine Baroni, Guido Battistoni, Giuseppe Belcari, Nicola Berti, Andrea Carra, Pietro Cerello, Piergiorgio Ciocca, Mario De Gregorio, Angelica De Simoni, Micol Del Sarto, Damiano Donetti, Marco Dong, Yunsheng Embriaco, Alessia Fantacci, Maria Evelina Ferrero, Veronica Fiorina, Elisa Fischetti, Marta Franciosini, Gaia Giraudo, Giuseppe Laruina, Francesco Maestri, Davide Magi, Marco Magro, Giuseppe Malekzadeh, Etesam Marafini, Michela Mattei, Ilaria Mazzoni, Enrico Mereu, Paolo Mirandola, Alfredo Morrocchi, Matteo Muraro, Silvia Orlandi, Ester Patera, Vincenzo Pennazio, Francesco Pullia, Marco Retico, Alessandra Rivetti, Angelo Da Rocha Rolo, Manuel Dionisio Rosso, Valeria Sarti, Alessio Schiavi, Angelo Sciubba, Adalberto Sportelli, Giancarlo Tampellini, Sara Toppi, Marco Traini, Giacomo Trigilio, Antonio Valle, Serena Marta Valvo, Francesca Vischioni, Barbara Vitolo, Viviana Wheadon, Richard Bisogni, Maria Giuseppina In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO |
title |
In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO |
title_full |
In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO |
title_fullStr |
In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO |
title_full_unstemmed |
In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO |
title_short |
In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO |
title_sort | in-vivo range verification analysis with in-beam pet data for patients treated with proton therapy at cnao |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549776/ https://www.ncbi.nlm.nih.gov/pubmed/36226070 http://dx.doi.org/10.3389/fonc.2022.929949 |
work_keys_str_mv | AT moglionimartina invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT kraanaafkechristine invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT baroniguido invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT battistonigiuseppe invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT belcarinicola invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT bertiandrea invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT carrapietro invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT cerellopiergiorgio invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT cioccamario invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT degregorioangelica invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT desimonimicol invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT delsartodamiano invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT donettimarco invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT dongyunsheng invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT embriacoalessia invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT fantaccimariaevelina invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT ferreroveronica invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT fiorinaelisa invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT fischettimarta invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT franciosinigaia invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT giraudogiuseppe invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT laruinafrancesco invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT maestridavide invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT magimarco invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT magrogiuseppe invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT malekzadehetesam invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT marafinimichela invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT matteiilaria invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT mazzonienrico invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT mereupaolo invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT mirandolaalfredo invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT morrocchimatteo invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT murarosilvia invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT orlandiester invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT pateravincenzo invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT pennaziofrancesco invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT pulliamarco invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT reticoalessandra invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT rivettiangelo invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT darocharolomanueldionisio invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT rossovaleria invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT sartialessio invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT schiaviangelo invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT sciubbaadalberto invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT sportelligiancarlo invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT tampellinisara invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT toppimarco invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT trainigiacomo invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT trigilioantonio invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT valleserenamarta invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT valvofrancesca invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT vischionibarbara invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT vitoloviviana invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT wheadonrichard invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao AT bisognimariagiuseppina invivorangeverificationanalysiswithinbeampetdataforpatientstreatedwithprotontherapyatcnao |