Pyroptosis in NLRP3 inflammasome-related atherosclerosis

Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are k...

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Autores principales: Zeng, Xiang, Liu, Dongling, Huo, Xia, Wu, Yue, Liu, Cuiqing, Sun, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549904/
https://www.ncbi.nlm.nih.gov/pubmed/36304814
http://dx.doi.org/10.15698/cst2022.10.272
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author Zeng, Xiang
Liu, Dongling
Huo, Xia
Wu, Yue
Liu, Cuiqing
Sun, Qinghua
author_facet Zeng, Xiang
Liu, Dongling
Huo, Xia
Wu, Yue
Liu, Cuiqing
Sun, Qinghua
author_sort Zeng, Xiang
collection PubMed
description Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are known pyroptosis molecular pathways including the caspase-1 depended canonical signaling pathway and the caspase-4/5/11 determined non-canonical signaling pathway. It is essential to explore the connection among NLRP3 inflammasome, pyroptosis and atherosclerosis, which may shed light on the potential therapeutic strategies that target pyroptosis in atherosclerotic treatment.
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spelling pubmed-95499042022-10-26 Pyroptosis in NLRP3 inflammasome-related atherosclerosis Zeng, Xiang Liu, Dongling Huo, Xia Wu, Yue Liu, Cuiqing Sun, Qinghua Cell Stress Review Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are known pyroptosis molecular pathways including the caspase-1 depended canonical signaling pathway and the caspase-4/5/11 determined non-canonical signaling pathway. It is essential to explore the connection among NLRP3 inflammasome, pyroptosis and atherosclerosis, which may shed light on the potential therapeutic strategies that target pyroptosis in atherosclerotic treatment. Shared Science Publishers OG 2022-10-10 /pmc/articles/PMC9549904/ /pubmed/36304814 http://dx.doi.org/10.15698/cst2022.10.272 Text en Copyright: © 2022 Zeng et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Review
Zeng, Xiang
Liu, Dongling
Huo, Xia
Wu, Yue
Liu, Cuiqing
Sun, Qinghua
Pyroptosis in NLRP3 inflammasome-related atherosclerosis
title Pyroptosis in NLRP3 inflammasome-related atherosclerosis
title_full Pyroptosis in NLRP3 inflammasome-related atherosclerosis
title_fullStr Pyroptosis in NLRP3 inflammasome-related atherosclerosis
title_full_unstemmed Pyroptosis in NLRP3 inflammasome-related atherosclerosis
title_short Pyroptosis in NLRP3 inflammasome-related atherosclerosis
title_sort pyroptosis in nlrp3 inflammasome-related atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549904/
https://www.ncbi.nlm.nih.gov/pubmed/36304814
http://dx.doi.org/10.15698/cst2022.10.272
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