Cargando…

In vitro and in silico assessment of new beta amino ketones with antiplasmodial activity

BACKGROUND: Based on the current need for new drugs against malaria, our study evaluated eight beta amino ketones in silico and in vitro for potential antimalarial activity. METHODS: Using the Brazilian Malaria Molecular Targets (BraMMT) and OCTOPUS® software programs, the pattern of interactions of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krombauer, Gabriela Camila, Guedes, Karla de Sena, Banfi, Felipe Fingir, Nunes, Renata Rachide, da Fonseca, Amanda Luisa, de Siqueira, Ezequias Pessoa, Bellei, Jéssica Côrrea Bezerra, Scopel, Kézia Katiani Gorza, Varotti, Fernando de Pilla, Sanchez, Bruno Antônio Marinho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Medicina Tropical - SBMT 2022
Materias:	Major Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549944/ https://www.ncbi.nlm.nih.gov/pubmed/36169491 http://dx.doi.org/10.1590/0037-8682-0590-2022

Ejemplares similares

Dehydrobufotenin extracted from the Amazonian toad Rhinella marina (Anura: Bufonidae) as a prototype molecule for the development of antiplasmodial drugs
por: Banfi, Felipe Finger, et al.
Publicado: (2021)

Polymorphism of the Fcγ receptor IIA and malaria morbidity
por: Braga, Érika Martins, et al.
Publicado: (2005)

Editorial: New advances in knowledge of the parasite-host relationship during malarial infection
por: Albrecht, Letusa, et al.
Publicado: (2022)

Antiplasmodial and Cytotoxic Activities of Toad Venoms from Southern Amazon, Brazil
por: Banfi, Felipe Finger, et al.
Publicado: (2016)

Antiplasmodial Activity of Hydroalcoholic Extract from Jucá (Libidibia ferrea) Pods
por: de Assis, Francisco Flávio Vieira, et al.
Publicado: (2023)

Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil
por: Alves, Uesley Vieira, et al.
Publicado: (2021)

Target-Guided Synthesis and Antiplasmodial Evaluation of a New Fluorinated 3-Alkylpyridine Marine Alkaloid Analog
por: Barbosa, Camila de Souza, et al.
Publicado: (2017)

Rational-Based Discovery of Novel β-Carboline Derivatives as Potential Antimalarials: From In Silico Identification of Novel Targets to Inhibition of Experimental Cerebral Malaria
por: Alves, Fernanda de Moura, et al.
Publicado: (2022)

Evaluation of antiplasmodial activity in silico and in vitro of N-acylhydrazone derivatives
por: Oliveira, Fernanda A., et al.
Publicado: (2022)

Brazilian malaria molecular targets (BraMMT): selected receptors for virtual high-throughput screening experiments
por: Nunes, Renata Rachide, et al.
Publicado: (2019)

Blood-stage antiplasmodial activity and oocyst formation-blockage of metallo copper-cinchonine complex
por: Morais, Camila Martins Gomes, et al.
Publicado: (2022)

Detection of amalgam tattoo in oral mucosa by wide-field optical fluorescence
por: Andrade, Sérgio Araújo, et al.
Publicado: (2018)

Health impacts caused by excessive sodium consumption in Brazil: results of the GBD 2019 study
por: Guedes, Larissa Fernanda Fonseca, et al.
Publicado: (2022)

Antimalarial Activity of 4-Metoxychalcones: Docking Studies as Falcipain/Plasmepsin Inhibitors, ADMET and Lipophilic Efficiency Analysis to Identify a Putative Oral Lead Candidate
por: de Oliveira, Michael Eder, et al.
Publicado: (2013)

Influence of Angiotensin-converting Enzyme Insertion/Deletion Gene Polymorphism in Progression of Chagas Heart Disease
por: Alves, Silvia Marinho Martins, et al.
Publicado: (2020)

Antiplasmodial Natural Products
por: Nogueira, Cláudio R., et al.
Publicado: (2011)

Successful application of virtual screening and molecular dynamics simulations against antimalarial molecular targets
por: Nunes, Renata Rachide, et al.
Publicado: (2016)

Laboratory-based study of drug resistance and genotypic profile of multidrug-resistant tuberculosis isolates in Salvador, Bahia, Brazil
por: Sousa, Erivelton de Oliveira, et al.
Publicado: (2022)

Use of wide-field optical fluorescence for visualization of oral biofilm in a patient with peri-implant mucositis: a new approach
por: Andrade, Sérgio Araújo, et al.
Publicado: (2021)

New linear antiplasmodial peptides related to angiotensin II
por: Silva, Adriana Farias, et al.
Publicado: (2015)

In vitro antiplasmodial activity of cepharanthine
por: Desgrouas, Camille, et al.
Publicado: (2014)

Antiplasmodial natural products: an update
por: Tajuddeen, Nasir, et al.
Publicado: (2019)

Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones
por: Lande, Duc Hoàng, et al.
Publicado: (2021)

Clinical and epidemiological profiles of patients with American cutaneous leishmaniasis from the states of Pernambuco and Amazonas, Brazil
por: de Melo, Maria Gabriella Nunes, et al.
Publicado: (2020)

A systematic review of the diagnostic aspects and use of Trypanosoma rangeli as an immunogen for Trypanosoma cruzi infection
por: Bayão, Taciana de Souza, et al.
Publicado: (2020)

Mortality and years of life lost to death or disability by interpersonal violence against women in Brazil: Global Burden of Disease Study, 1990 and 2019
por: Pinto, Isabella Vitral, et al.
Publicado: (2022)

Burden of syphilis in Brazil and federated units, 1990-2016: estimates from the Global Burden of Disease Study 2019
por: Bezerra, Juliana Maria Trindade, et al.
Publicado: (2022)

Factors Associated with the Abandonment of Tuberculosis Treatment in Brazil: A Systematic Review
por: de Lucena, Larissa Araújo, et al.
Publicado: (2023)

Phenotypic and genotypic analysis of biofilm production by Pseudomonas aeruginosa isolates from infection and colonization samples
por: Rodrigues, Rodrigo Lira, et al.
Publicado: (2020)

Diversity of biting midges Culicoides (Diptera: Ceratopogonidae), potential vectors of disease, in different environments in an Amazonian rural settlement, Brazil
por: Farias, Emanuelle de Sousa, et al.
Publicado: (2020)

Epidemiology of accidents involving venomous animals in the State of Ceará, Brazil (2007-2019)
por: Braga, Jacqueline Ramos Machado, et al.
Publicado: (2021)

Exploration of thiaheterocyclic hHDAC6 inhibitors as potential antiplasmodial agents
por: Vreese, Rob De, et al.
Publicado: (2017)

Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil
por: Monteiro, Mísia Joyner de Sousa Dias, et al.
Publicado: (2021)

Antiplasmodial, antinociceptive and antipyretic potential of the stem bark extract of Burkea africana and identification of its antiplasmodial-active fraction
por: Ezenyi, Ifeoma C., et al.
Publicado: (2021)

Seroprevalence and factors associated with SARS-CoV-2 infection among education workers after the first wave: the first cross-sectional study in Brazil
por: França, Pâmela de Castro, et al.
Publicado: (2022)

Factors associated with deaths from dengue in a city in a metropolitan region in Southeastern Brazil: a case-control study
por: de Sousa, Selma Costa, et al.
Publicado: (2022)

The JNK Pathway Is a Key Mediator of Anopheles gambiae Antiplasmodial Immunity
por: Garver, Lindsey S., et al.
Publicado: (2013)

COVID-19 pandemic: multilevel dental technical guidelines based on new scientific evidence
por: Andrade, Sérgio Araújo, et al.
Publicado: (2022)

Synthesis and antiplasmodial assessment of nitazoxanide and analogs as new antimalarial candidates
por: Irabuena, Camila, et al.
Publicado: (2022)

Excess Mortality due to natural causes among whites and blacks during the COVID-19 pandemic in Brazil
por: Teixeira, Renato Azeredo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7of7tgpo3bg4aa9hajbfpf39hh