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Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia

PURPOSE: Insomnia, a chronic condition affecting 50% of older adults, is often accompanied by cognitive decline. The mechanism underlying this comorbidity is not fully understood. A growing literature suggests the importance of gut microbiota for brain function. We tested associations between sleep...

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Autores principales: Haimov, Iris, Magzal, Faiga, Tamir, Snait, Lalzar, Maya, Asraf, Kfir, Milman, Uzi, Agmon, Maayan, Shochat, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550024/
https://www.ncbi.nlm.nih.gov/pubmed/36225322
http://dx.doi.org/10.2147/NSS.S377114
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author Haimov, Iris
Magzal, Faiga
Tamir, Snait
Lalzar, Maya
Asraf, Kfir
Milman, Uzi
Agmon, Maayan
Shochat, Tamar
author_facet Haimov, Iris
Magzal, Faiga
Tamir, Snait
Lalzar, Maya
Asraf, Kfir
Milman, Uzi
Agmon, Maayan
Shochat, Tamar
author_sort Haimov, Iris
collection PubMed
description PURPOSE: Insomnia, a chronic condition affecting 50% of older adults, is often accompanied by cognitive decline. The mechanism underlying this comorbidity is not fully understood. A growing literature suggests the importance of gut microbiota for brain function. We tested associations between sleep quality and cognitive performance with gut microbiota in older adults with insomnia. PATIENTS AND METHODS: Seventy-two older adults with insomnia (age 73.2 ± 5.73 years, 56 females) provided stool samples for gut microbial sequencing. Microbiota profile was determined using the DADA2 bioinformatics pipeline. Cognition was assessed with the Cambridge Neuropsychological Test Automated Battery. Objective sleep quality was monitored by a two-week actigraphic recording, and participants completed the Insomnia Severity Index (ISI). We used partial canonical correspondence analysis (pCCA) to examine the relative contribution of insomnia, based on actigraphic sleep efficiency (SE) and ISI, and of cognitive status, based on the Multitasking test of Median Reaction Latency (MTTLMD) and the Spatial Working Memory Between Errors (SWMBE), to variance in microbiota composition. We used Pearson correlations to correlate insomnia and cognitive status parameters with microbiota amplicon sequence variants, genera, and families. RESULTS: The pCCA revealed that sleep quality and cognitive performance explained a variation of 7.5–7.9% in gut microbiota composition in older adults with insomnia. Correlation analysis demonstrated that Lachnoclostridium (genus) correlates positively with SE (r=0.42; P=0.05) and negatively with MTTLMD (r=−0.29; P=0.03), whereas Blautia (genus) correlates negatively with MTTLMD (r=−0.31; P=0.01). CONCLUSION: Findings demonstrate the associations of sleep quality and cognitive performance with variance in gut microbiota composition and with specific genus abundance in older adults with insomnia. Further studies should validate the findings, determine causal relationships, and evaluate potential interventions for the comorbidity of insomnia and cognitive impairment in older adults with insomnia.
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spelling pubmed-95500242022-10-11 Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia Haimov, Iris Magzal, Faiga Tamir, Snait Lalzar, Maya Asraf, Kfir Milman, Uzi Agmon, Maayan Shochat, Tamar Nat Sci Sleep Original Research PURPOSE: Insomnia, a chronic condition affecting 50% of older adults, is often accompanied by cognitive decline. The mechanism underlying this comorbidity is not fully understood. A growing literature suggests the importance of gut microbiota for brain function. We tested associations between sleep quality and cognitive performance with gut microbiota in older adults with insomnia. PATIENTS AND METHODS: Seventy-two older adults with insomnia (age 73.2 ± 5.73 years, 56 females) provided stool samples for gut microbial sequencing. Microbiota profile was determined using the DADA2 bioinformatics pipeline. Cognition was assessed with the Cambridge Neuropsychological Test Automated Battery. Objective sleep quality was monitored by a two-week actigraphic recording, and participants completed the Insomnia Severity Index (ISI). We used partial canonical correspondence analysis (pCCA) to examine the relative contribution of insomnia, based on actigraphic sleep efficiency (SE) and ISI, and of cognitive status, based on the Multitasking test of Median Reaction Latency (MTTLMD) and the Spatial Working Memory Between Errors (SWMBE), to variance in microbiota composition. We used Pearson correlations to correlate insomnia and cognitive status parameters with microbiota amplicon sequence variants, genera, and families. RESULTS: The pCCA revealed that sleep quality and cognitive performance explained a variation of 7.5–7.9% in gut microbiota composition in older adults with insomnia. Correlation analysis demonstrated that Lachnoclostridium (genus) correlates positively with SE (r=0.42; P=0.05) and negatively with MTTLMD (r=−0.29; P=0.03), whereas Blautia (genus) correlates negatively with MTTLMD (r=−0.31; P=0.01). CONCLUSION: Findings demonstrate the associations of sleep quality and cognitive performance with variance in gut microbiota composition and with specific genus abundance in older adults with insomnia. Further studies should validate the findings, determine causal relationships, and evaluate potential interventions for the comorbidity of insomnia and cognitive impairment in older adults with insomnia. Dove 2022-10-06 /pmc/articles/PMC9550024/ /pubmed/36225322 http://dx.doi.org/10.2147/NSS.S377114 Text en © 2022 Haimov et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Haimov, Iris
Magzal, Faiga
Tamir, Snait
Lalzar, Maya
Asraf, Kfir
Milman, Uzi
Agmon, Maayan
Shochat, Tamar
Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia
title Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia
title_full Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia
title_fullStr Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia
title_full_unstemmed Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia
title_short Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia
title_sort variation in gut microbiota composition is associated with sleep quality and cognitive performance in older adults with insomnia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550024/
https://www.ncbi.nlm.nih.gov/pubmed/36225322
http://dx.doi.org/10.2147/NSS.S377114
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