Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature

BACKGROUND: Chronic Chagas Cardiomyopathy (CCC) usually develops between 10 and 20 years after the first parasitic infection and is one of the leading causes of end-stage heart failure in Latin America. Despite the great inter-individual variability in CCC susceptibility (only 30% of infected indivi...

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Detalles Bibliográficos
Autores principales: Sabino, Ester Cerdeira, Franco, Lucas Augusto Moysés, Venturini, Gabriela, Velho Rodrigues, Mariliza, Marques, Emanuelle, de Oliveira-da Silva, Lea Campos, Martins, Larissa Natany Almeida, Ferreira, Ariela Mota, Almeida, Paulo Emílio Clementino, Silva, Felipe Dias Da, Leite, Sâmara Fernandes, Nunes, Maria do Carmo Pereira, Haikal, Desiree Sant’Ana, Oliveira, Claudia Di Lorenzo, Cardoso, Clareci Silva, Seidman, Jonathan G., Seidman, Christine E., Casas, Juan P., Ribeiro, Antonio Luiz Pinho, Krieger, Jose E., Pereira, Alexandre C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550069/
https://www.ncbi.nlm.nih.gov/pubmed/36215317
http://dx.doi.org/10.1371/journal.pntd.0010725

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