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Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity

Decreased BDNF and impaired TRKB signaling contribute to neurodegeneration in Alzheimer’s disease (AD). We have shown previously that coumarin derivative LM-031 enhanced CREB/BDNF/BCL2 pathway. In this study we explored if LM-031 analogs LMDS-1 to -4 may act as TRKB agonists to protect SH-SY5Y cells...

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Detalles Bibliográficos
Autores principales:	Chiu, Ya-Jen, Lin, Te-Hsien, Chang, Kuo-Hsuan, Lin, Wenwei, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Chen, Chiung-Mei, Sun, Ying-Chieh, Lee-Chen, Guey-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550238/ https://www.ncbi.nlm.nih.gov/pubmed/36170028 http://dx.doi.org/10.18632/aging.204306

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