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∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis

Long-term exposure to high glucose leads to β-cell dysfunction and death. Fibroblast growth factor 1 (FGF1) has emerged as a promising diabetes treatment, but its pharmaceutical role and mechanism against glucolipotoxicity-induced β-cell dysfunction remain uncharacterized. Wild-type FGF1 (FGF1(WT))...

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Detalles Bibliográficos
Autores principales:	Chen, Qiong, Chen, Xinwei, Jia, Zhenyu, Du, Yali, Zhang, Shujun, Xu, Wenxin, Pan, Beibin, Lou, Jiaxin, Zhou, Jianhui, Zhou, Jie, Sun, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550415/ https://www.ncbi.nlm.nih.gov/pubmed/36225175 http://dx.doi.org/10.1155/2022/1231970

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