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A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma
A 68-year-old woman presented with follicular lymphoma complicated by IgG kappa-positive multiple myeloma. In this case, both follicular lymphoma and plasma cells were positive for BCL2 by immunostaining. T-cell association in the FL and MM was also analyzed in this case. Some CD3-positive T-cells w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550423/ https://www.ncbi.nlm.nih.gov/pubmed/36225194 http://dx.doi.org/10.1155/2022/3076968 |
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author | Tsutsumi, Yutaka Ito, Shinich Kobayashi, Mirei Teshima, Takanori |
author_facet | Tsutsumi, Yutaka Ito, Shinich Kobayashi, Mirei Teshima, Takanori |
author_sort | Tsutsumi, Yutaka |
collection | PubMed |
description | A 68-year-old woman presented with follicular lymphoma complicated by IgG kappa-positive multiple myeloma. In this case, both follicular lymphoma and plasma cells were positive for BCL2 by immunostaining. T-cell association in the FL and MM was also analyzed in this case. Some CD3-positive T-cells were found around the plasma cells. These cells were mainly CD8-positive T-cells and not CD4-positive T-cells. These results suggest that CD4-positive T-cells were not associated with the proliferation of the plasma cells in this case. Although the FL that developed was initially positive for BCL2 protein, this does not indicate that plasma cells were derived from FL cells because of the eventual complication that occurred in this case. Furthermore, in this case, rituximab and bendamustine were effective for FL. They were not effective for MM, however, demonstrating that additional treatment options are necessary for the simultaneous treatment of BCL2-positive MM with FL. |
format | Online Article Text |
id | pubmed-9550423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-95504232022-10-11 A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma Tsutsumi, Yutaka Ito, Shinich Kobayashi, Mirei Teshima, Takanori Case Rep Hematol Case Report A 68-year-old woman presented with follicular lymphoma complicated by IgG kappa-positive multiple myeloma. In this case, both follicular lymphoma and plasma cells were positive for BCL2 by immunostaining. T-cell association in the FL and MM was also analyzed in this case. Some CD3-positive T-cells were found around the plasma cells. These cells were mainly CD8-positive T-cells and not CD4-positive T-cells. These results suggest that CD4-positive T-cells were not associated with the proliferation of the plasma cells in this case. Although the FL that developed was initially positive for BCL2 protein, this does not indicate that plasma cells were derived from FL cells because of the eventual complication that occurred in this case. Furthermore, in this case, rituximab and bendamustine were effective for FL. They were not effective for MM, however, demonstrating that additional treatment options are necessary for the simultaneous treatment of BCL2-positive MM with FL. Hindawi 2022-10-03 /pmc/articles/PMC9550423/ /pubmed/36225194 http://dx.doi.org/10.1155/2022/3076968 Text en Copyright © 2022 Yutaka Tsutsumi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Tsutsumi, Yutaka Ito, Shinich Kobayashi, Mirei Teshima, Takanori A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma |
title | A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma |
title_full | A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma |
title_fullStr | A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma |
title_full_unstemmed | A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma |
title_short | A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma |
title_sort | rare case of bcl2-positive multiple myeloma complicated with follicular lymphoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550423/ https://www.ncbi.nlm.nih.gov/pubmed/36225194 http://dx.doi.org/10.1155/2022/3076968 |
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