Investigating the role of common and rare variants in multiplex multiple sclerosis families reveals an increased burden of common risk variation

Many multiple sclerosis (MS)-associated common risk variants as well as candidate low-frequency and rare variants have been identified; however, approximately half of MS heritability remains unexplained. We studied seven multiplex MS families, six of which with parental consanguinity, to identify ge...

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Detalles Bibliográficos
Autores principales: Everest, Elif, Ahangari, Mohammad, Uygunoglu, Ugur, Tutuncu, Melih, Bulbul, Alper, Saip, Sabahattin, Duman, Taskin, Sezerman, Ugur, Reich, Daniel S., Riley, Brien P., Siva, Aksel, Tahir Turanli, Eda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550807/
https://www.ncbi.nlm.nih.gov/pubmed/36216875
http://dx.doi.org/10.1038/s41598-022-21484-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550807/
https://www.ncbi.nlm.nih.gov/pubmed/36216875
http://dx.doi.org/10.1038/s41598-022-21484-x

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