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Enterotypes in asthenospermia patients with obesity

The essence of enterotypes is stratifying the entire human gut microbiome, which modulates the association between diet and disease risk. A study was designed at the Center of Reproductive Medicine, Shengjing Hospital of China Medical University and Jinghua Hospital of Shenyang. Prevotella and Bacte...

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Autores principales: Jiao, Jiao, Xu, Peng, Wang, Xiaobin, Xing, Ze, Dong, Sitong, Li, Gaoyu, Yao, Xinrui, Guo, Renhao, Feng, Tao, Yao, Weifan, Pan, Bochen, Zhu, Xuan, Wang, Xiuxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550853/
https://www.ncbi.nlm.nih.gov/pubmed/36216963
http://dx.doi.org/10.1038/s41598-022-20574-0
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author Jiao, Jiao
Xu, Peng
Wang, Xiaobin
Xing, Ze
Dong, Sitong
Li, Gaoyu
Yao, Xinrui
Guo, Renhao
Feng, Tao
Yao, Weifan
Pan, Bochen
Zhu, Xuan
Wang, Xiuxia
author_facet Jiao, Jiao
Xu, Peng
Wang, Xiaobin
Xing, Ze
Dong, Sitong
Li, Gaoyu
Yao, Xinrui
Guo, Renhao
Feng, Tao
Yao, Weifan
Pan, Bochen
Zhu, Xuan
Wang, Xiuxia
author_sort Jiao, Jiao
collection PubMed
description The essence of enterotypes is stratifying the entire human gut microbiome, which modulates the association between diet and disease risk. A study was designed at the Center of Reproductive Medicine, Shengjing Hospital of China Medical University and Jinghua Hospital of Shenyang. Prevotella and Bacteroides were analyzed in 407 samples of stool, including 178 men with enterotype B (61 normal, 117 overweight/obese) and 229 men with enterotype P (74 normal, 155 overweight/obese). The ratio between Prevotella and Bacteroides abundance, P/B, was used as a simplified way to distinguish the predominant enterotype. In enterotype P group (P/B ≥ 0.01), obesity was a risk factor for a reduced rate of forward progressive sperm motility (odds ratio [OR] 3.350; 95% confidence interval [CI] 1.881–5.966; P < 0.001), and a reduced rate of total sperm motility (OR 4.298; 95% CI 2.365–7.809; P < 0.001). Obesity was also an independent risk factor (OR 3.131; 95% CI 1.749–5.607; P < 0.001) after adjusting follicle-stimulating hormone. In enterotype P, body mass index, as a diagnostic indicator of a reduced rate of forward progressive sperm motility and a decreased rate of decreased total sperm motility, had AUC values of 0.627 (P = 0.001) and 0.675 (P < 0.0001), respectively, which were significantly higher than the predicted values in all patients. However, in enterotype B group (P < 0.01), obesity was not a risk factor for asthenospermia, where no significant difference between obesity and sperm quality parameters was observed. This study is tried to introduce enterotypes as a population-based individualized classification index to investigate the correlation between BMI and asthenospermia. In our study, overweight/obese men with enterotype P were found to have poorer sperm quality. however, sperm quality was not associated with overweight/obese in men with enterotype B. Thereof, BMI is a risk factor for asthenospermia only in men with enterotype P, but not in men with enterotype B.
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spelling pubmed-95508532022-10-12 Enterotypes in asthenospermia patients with obesity Jiao, Jiao Xu, Peng Wang, Xiaobin Xing, Ze Dong, Sitong Li, Gaoyu Yao, Xinrui Guo, Renhao Feng, Tao Yao, Weifan Pan, Bochen Zhu, Xuan Wang, Xiuxia Sci Rep Article The essence of enterotypes is stratifying the entire human gut microbiome, which modulates the association between diet and disease risk. A study was designed at the Center of Reproductive Medicine, Shengjing Hospital of China Medical University and Jinghua Hospital of Shenyang. Prevotella and Bacteroides were analyzed in 407 samples of stool, including 178 men with enterotype B (61 normal, 117 overweight/obese) and 229 men with enterotype P (74 normal, 155 overweight/obese). The ratio between Prevotella and Bacteroides abundance, P/B, was used as a simplified way to distinguish the predominant enterotype. In enterotype P group (P/B ≥ 0.01), obesity was a risk factor for a reduced rate of forward progressive sperm motility (odds ratio [OR] 3.350; 95% confidence interval [CI] 1.881–5.966; P < 0.001), and a reduced rate of total sperm motility (OR 4.298; 95% CI 2.365–7.809; P < 0.001). Obesity was also an independent risk factor (OR 3.131; 95% CI 1.749–5.607; P < 0.001) after adjusting follicle-stimulating hormone. In enterotype P, body mass index, as a diagnostic indicator of a reduced rate of forward progressive sperm motility and a decreased rate of decreased total sperm motility, had AUC values of 0.627 (P = 0.001) and 0.675 (P < 0.0001), respectively, which were significantly higher than the predicted values in all patients. However, in enterotype B group (P < 0.01), obesity was not a risk factor for asthenospermia, where no significant difference between obesity and sperm quality parameters was observed. This study is tried to introduce enterotypes as a population-based individualized classification index to investigate the correlation between BMI and asthenospermia. In our study, overweight/obese men with enterotype P were found to have poorer sperm quality. however, sperm quality was not associated with overweight/obese in men with enterotype B. Thereof, BMI is a risk factor for asthenospermia only in men with enterotype P, but not in men with enterotype B. Nature Publishing Group UK 2022-10-10 /pmc/articles/PMC9550853/ /pubmed/36216963 http://dx.doi.org/10.1038/s41598-022-20574-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Jiao, Jiao
Xu, Peng
Wang, Xiaobin
Xing, Ze
Dong, Sitong
Li, Gaoyu
Yao, Xinrui
Guo, Renhao
Feng, Tao
Yao, Weifan
Pan, Bochen
Zhu, Xuan
Wang, Xiuxia
Enterotypes in asthenospermia patients with obesity
title Enterotypes in asthenospermia patients with obesity
title_full Enterotypes in asthenospermia patients with obesity
title_fullStr Enterotypes in asthenospermia patients with obesity
title_full_unstemmed Enterotypes in asthenospermia patients with obesity
title_short Enterotypes in asthenospermia patients with obesity
title_sort enterotypes in asthenospermia patients with obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550853/
https://www.ncbi.nlm.nih.gov/pubmed/36216963
http://dx.doi.org/10.1038/s41598-022-20574-0
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